Transcriptome analysis of the effect of RAD52 knockout on olaparib response in BRCA2-deficient, olaparib-resistant murine ovarian cancer cells (ID8-OR)
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × Scramble, vehicle, vs 3 × Rad52 KO1, vehicle, vs 3 × Scramble, olaparib, vs 3 × Rad52 KO1, olaparib,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Targeting RAD52 overcomes PARP inhibitor resistance in preclinical Brca2-deficient ovarian cancer modelbioRxiv : the preprint server for biology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE302064_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1288437 and SRA study SRP599299. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9095213 Scramble, vehicle, replicate 1 Scramble, vehicle,
- GSM9095214 Scramble, vehicle, replicate 2 Scramble, vehicle,
- GSM9095215 Scramble, vehicle, replicate 3 Scramble, vehicle,
- GSM9095216 Rad52 KO1, vehicle, replicate 1 Rad52 KO1, vehicle,
- GSM9095217 Rad52 KO1, vehicle, replicate 2 Rad52 KO1, vehicle,
- GSM9095218 Rad52 KO1, vehicle, replicate 3 Rad52 KO1, vehicle,
- GSM9095219 Scramble, olaparib, replicate 1 Scramble, olaparib,
- GSM9095220 Scramble, olaparib, replicate 2 Scramble, olaparib,
- GSM9095221 Scramble, olaparib, replicate 3 Scramble, olaparib,
- GSM9095222 Rad52 KO1, olaparib, replicate 1 Rad52 KO1, olaparib,
- GSM9095223 Rad52 KO1, olaparib, replicate 2 Rad52 KO1, olaparib,
- GSM9095224 Rad52 KO1, olaparib, replicate 3 Rad52 KO1, olaparib,
No close match found for this topic, so these are simply the most-viewed datasets of the same kind.
- GSE293709 Transcriptome analysis in the prefrontal cortex of different ASD mouse models treated with drug 1565 samples
- GSE269748 A single-cell atlas deconstructs heterogeneity across multiple models in murine traumatic brain injury and identifies novel cell-specific targets 36 samples
- GSE304945 Tumor-borne ADAMTSL4 drives cancer cachexia via TGFβ signaling pathway 32 samples
- GSE300288 Single-cell and spatial transcriptomics analysis of tobacco-associated lung adenocarcinoma development, and in response to targeting inflammation alone or in combination with immune checkpoint blockade in precancerous phase [scRNA-seq] 31 samples
- GSE322551 Engineered bacteria as exogenous organelle mimics restore PTEN and p53 tumor suppressor functions for cancer therapy 30 samples
- GSE338763 Inflammatory Neuropathy in Mouse and Primate Models of Colorectal Cancer 24 samples
- GSE237260 Transcriptome Analysis Reveals Gene Expression Changes in a mouse Model of Hyperoxia-induced acute lung injury 12 samples
- GSE329539 Hypothalamic transcriptomic response to High-Fat Diet induced obesity: modulatory effects of Resveratrol, Curcumin, and Aged Garlic Extract. 12 samples
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.