Beta cell-specific PAK1 enrichment ameliorates diet-induced glucose intolerance by promoting insulin biogenesis and minimizing beta cell apoptosis
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 22 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 22 samples: 22 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Beta cell-specific PAK1 enrichment ameliorates diet-induced glucose intolerance in mice by promoting insulin biogenesis and minimising beta cell apoptosisDiabetologia · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE239382_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA998939 and SRA study SRP451644. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 22 sample titles: 22 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7662985 p84-myc-PAK1
- GSM7662986 p74-myc-PAK1
- GSM7663942 Donor3, Ctrl
- GSM7663943 Donor3, PAK1
- GSM7663944 Donor4, Ctrl
- GSM7663945 Donor4, PAK1
- GSM7663946 Donor5, Ctrl
- GSM7663947 Donor5, PAK1
- GSM7663948 Donor8, PAK1
- GSM7663949 Donor8, Ctrl
- GSM7663950 Donor9, Ctrl
- GSM7663951 Donor9, PAK1
- GSM7663952 Donor10, Ctrl
- GSM7663953 Donor10, PAK1
- GSM7663954 Donor 13, Ctrl
- GSM7663955 Donor 13, PAK1
- GSM7663956 Donor 14, Ctrl
- GSM7663957 Donor 14, PAK1
- GSM7663958 Donor 15, Ctrl
- GSM7663959 Donor 15, PAK1
- GSM7663960 Donor 16, Ctrl
- GSM7663961 Donor 16, PAK1
- GSE239381 Beta cell-specific PAK1 enrichment ameliorates diet-induced glucose intolerance by promoting insulin biogenesis and minimizing beta cell apoptosis [RNA-Seq] 20 samples shares pak1, cell-specific, diet-induced, ameliorates, intolerance, enrichment, biogenesis, minimizing
- GSE239306 Beta cell-specific PAK1 enrichment ameliorates diet-induced glucose intolerance by promoting insulin biogenesis and minimizing beta cell apoptosis [ChIP-Seq] 2 samples shares pak1, cell-specific, diet-induced, ameliorates, intolerance, enrichment, biogenesis, minimizing
- GSE237959 ZBTB48 is a pioneer factor regulating B-cell-specific CIITA expression. 36 samples shares cell-specific
- GSE179613 Human epigenetic and transcriptional T cell differentiation atlas for identifying functional T cell-specific enhancers 531 samples shares cell-specific
- GSE282733 Genetic Effects in Response to Exercise and Diet-induced Weight-loss in Human Skeletal Muscle Tissues 108 samples shares diet-induced
- GSE316614 Targeting mutation-agnostic disease pathways ameliorates ciliopathy-related mesenchymal drift in RPE 69 samples shares ameliorates
- GSE297984 Chemical reprogramming ameliorates cellular hallmarks of aging and extends lifespan 24 samples shares ameliorates
- GSE266113 Cannabidiol ameliorates mitochondrial disease via PPARg activation 24 samples shares ameliorates
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.