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Comparing the chromatin accessibility landscapes of WT organoids, RXRi organoids and APCko tumoroids

GSE239755 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 7 samples Submitted 2024/10/17 Platform GPL24247
Summary
To compare the effects of RXR inhibition to APC depletion on chromatin landscapes, WT organoids were treated with either HX531 (RXRi) or vehicle (WT). APCko tumorids treated with vehicle only were used as a benchmark. We then performed differential accessibility analysis using data obtained from ATAC-seq of the indicated organoid lines.
Published in
Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer
Mzoughi S, Schwarz M, Wang X et al. · Nature genetics 2025 · PMID 39930084 · doi:10.1038/s41588-024-02058-1
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Also filed as BioProject PRJNA1000919 and SRA study SRP452509. Searching any of these in the dataset finder brings you back here.

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