Comparison of unmodified and modified mRNA platforms for Andes virus mRNA vaccine in rodent models
RNA-seq (gene expression) · mouse · 32 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 32 samples: 32 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Comparison of uridine and N1-methylpseudouridine mRNA platforms in development of an Andes virus vaccineNature communications · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE240064_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1002143 and SRA study SRP453339. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 32 sample titles: 32 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7680764 Positive control, biol replicate 1, scRNA-seq
- GSM7680765 Positive control, biol replicate 2, scRNA-seq
- GSM7680766 Positive control, biol replicate 3, scRNA-seq
- GSM7680767 Positive control, biol replicate 4, scRNA-seq
- GSM7680768 Pseudouridine vaccine, biol replicate 1, scRNA-seq
- GSM7680769 Pseudouridine vaccine, biol replicate 2, scRNA-seq
- GSM7680770 Pseudouridine vaccine, biol replicate 3, scRNA-seq
- GSM7680771 Pseudouridine vaccine, biol replicate 4, scRNA-seq
- GSM7680772 Uridine vaccine, biol replicate 1, scRNA-seq
- GSM7680773 Uridine vaccine biol replicate 2, scRNA-seq
- GSM7680774 Uridine vaccine, biol replicate 3, scRNA-seq
- GSM7680775 Uridine vaccine, biol replicate 4, scRNA-seq
- GSM7680776 Negative control, biol replicate 1, scRNA-seq
- GSM7680777 Negative control, biol replicate 2, scRNA-seq
- GSM7680778 Negative control, biol replicate 3, scRNA-seq
- GSM7680779 Negative control, biol replicate 4, scRNA-seq
- GSM7680780 Positive control, biol replicate 1, V(D)J
- GSM7680781 Positive control, biol replicate 2, V(D)J
- GSM7680782 Positive control, biol replicate 3, V(D)J
- GSM7680783 Positive control, biol replicate 4, V(D)J
- GSM7680784 Pseudouridine vaccine, biol replicate 1, V(D)J
- GSM7680785 Pseudouridine vaccine, biol replicate 2, V(D)J
- GSM7680786 Pseudouridine vaccine, biol replicate 3, V(D)J
- GSM7680787 Pseudouridine vaccine, biol replicate 4, V(D)J
- GSM7680788 Uridine vaccine, biol replicate 1, V(D)J
- GSM7680789 Uridine vaccine biol replicate 2, V(D)J
- GSM7680790 Uridine vaccine, biol replicate 3, V(D)J
- GSM7680791 Uridine vaccine, biol replicate 4, V(D)J
- GSM7680792 Negative control, biol replicate 1, V(D)J
- GSM7680793 Negative control, biol replicate 2, V(D)J
- GSM7680794 Negative control, biol replicate 3, V(D)J
- GSM7680795 Negative control, biol replicate 4, V(D)J
- GSE240062 Andes virus mRNA vaccines: comparison of unmodified and modified mRNA platforms [scRNA-seq] 16 samples shares comparison, unmodified, platforms, modified, vaccine, andes, virus
- GSE254967 A mouse model of human coronavirus HCoV-NL63 infection: comparison with rhinovirus-A1B 18 samples shares comparison, virus
- GSE280660 Transcriptional analysis of blood-borne immune cells induced by VSV-based vaccines: A comparison before and after immunization 18 samples shares comparison, vaccine
- GSE309156 Mannose-Modified Tobacco Mosaic Virus-Mediated Macrophage Regulation Inhibits Pulmonary Fibrosis Progression 9 samples shares modified, virus
- GSE241850 Psychological stress-induced ALKBH5 deficiency promotes tumour innervation and pancreatic cancer progression via extracellular vesicle transfer of m6A-modified RNAs 57 samples shares modified
- GSE271114 Effect of Matrigel, Laminin and Poly-L-Ornithine coating substrates on primary enteric glial cells and comparison to in vivo enteric glia 35 samples shares comparison
- GSE240541 Cross-species comparison reveals therapeutic vulnerabilities halting glioblastoma progression 1564 samples shares comparison
- GSE282998 Comparison of phenotypic and transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in wild-type and PPARα knockout mouse livers 192 samples shares comparison
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.