Upregulated FoxO1 promotes arrhythmogenesis in mice with heart failure and preserved ejection fraction
RNA-seq (gene expression) · mouse · 27 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 27 samples: 10 × Control vs 5 × HFpEF vs 5 × HFpEF-FoxO1-sh vs 4 × HFpEF-scGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Upregulated FoxO1 promotes arrhythmogenesis in mice with heart failure and preserved ejection fractionNature communications · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE240404_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1003518 and SRA study SRP454091. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 24 samples.
How we read this: 4 replicated groups read from 27 sample titles; they account for 24 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7697526 Control 1 Control
- GSM7697527 Control 2 Control
- GSM7697528 Control 3 Control
- GSM7697529 Control 4 Control
- GSM7697530 Control 5 Control
- GSM7697531 HFpEF 1 HFpEF
- GSM7697532 HFpEF 2 HFpEF
- GSM7697533 HFpEF 3 HFpEF
- GSM7697534 HFpEF 4 HFpEF
- GSM7697535 HFpEF 5 HFpEF
- GSM7697536 Control 1 Control
- GSM7697537 Control 2 Control
- GSM7697538 Control 3 Control
- GSM7697539 Control 4 Control
- GSM7697540 Control 5 Control
- GSM7697541 HFpEF-scr 1 HFpEF-sc
- GSM7697542 HFpEF-scr 2 HFpEF-sc
- GSM7697543 HFpEF-scr 3 HFpEF-sc
- GSM7697544 HFpEF-scr 4 HFpEF-sc
- GSM7697545 HFpEF-FoxO1-sh 1 HFpEF-FoxO1-sh
- GSM7697546 HFpEF-FoxO1-sh 2 HFpEF-FoxO1-sh
- GSM7697547 HFpEF-FoxO1-sh 3 HFpEF-FoxO1-sh
- GSM7697548 HFpEF-FoxO1-sh 4 HFpEF-FoxO1-sh
- GSM7697549 HFpEF-FoxO1-sh 5 HFpEF-FoxO1-sh
- GSM7697560 Control, 4 pooled samples
- GSM7697561 HFpEF-scr, 4 pooled samples
- GSM7697562 HFpEF-FoxO1-sh, 4 pooled samples
- GSE240401 Upregulated FoxO1 promotes arrhythmogenesis in mice with heart failure and preserved ejection fraction [control vs HF] 14 samples shares foxo1, arrhythmogenesis, upregulated, preserved, promotes, ejection, fraction, failure
- GSE240400 Upregulated FoxO1 promotes arrhythmogenesis in mice with heart failure and preserved ejection fraction [6 wks] 10 samples shares foxo1, arrhythmogenesis, upregulated, preserved, promotes, ejection, fraction, failure
- GSE240403 Upregulated FoxO1 promotes arrhythmogenesis in mice with heart failure and preserved ejection fraction [scRNA-seq] 3 samples shares foxo1, arrhythmogenesis, upregulated, preserved, promotes, ejection, fraction, failure
- GSE269053 Two-hit mouse model of heart failure with preserved ejection fraction combining diet-induced obesity and renin-mediated hypertension 21 samples shares preserved, ejection, fraction, failure
- GSE289265 Chromatin Remodelers in Cardiometabolic Heart Failure with Preserved Ejection Fraction 16 samples shares preserved, ejection, fraction, failure
- GSE212839 The protective effects of exercise training on heart failure with preserved ejection fraction 12 samples shares preserved, ejection, fraction, failure
- GSE249411 Bulk RNA-seq comparison of TYA018 HDAC6 inhibition vs vehicle after a single dose treatment in Mus Musculus to treat heart failure with preserved ejection fraction 12 samples shares preserved, ejection, fraction, failure
- GSE218733 Cardiac reprogramming and Gata4 overexpression reduce fibrosis and improve diastolic dysfunction in heart failure with preserved ejection fraction [RNA-seq] 9 samples shares preserved, ejection, fraction, failure
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.