A-MYB substitutes for B-MYB in activating cell cycle genes and in stimulating proliferation
RNA-seq (gene expression) · human · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 16 samples: 8 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- A-MYB substitutes for B-MYB in activating cell cycle genes and in stimulating proliferationNucleic acids research · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE240799_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1005271 and SRA study SRP454939. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 8 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7709668 HCT116_siCtrl_rep1 HCT116_siCtrl
- GSM7709669 HCT116_siCtrl_rep2 HCT116_siCtrl
- GSM7709670 HCT116_siMYBL1_rep1 HCT116_siMYBL1
- GSM7709671 HCT116_siMYBL1_rep2 HCT116_siMYBL1
- GSM7709672 HCT116_siMYBL2_rep1 HCT116_siMYBL2
- GSM7709673 HCT116_siMYBL2_rep2 HCT116_siMYBL2
- GSM7709674 HCT116_siMYBL1-siMYBL2_rep1 HCT116_siMYBL1-siMYBL2
- GSM7709675 HCT116_siMYBL1-siMYBL2_rep2 HCT116_siMYBL1-siMYBL2
- GSM7709676 U2OS_siCtrl_rep1 U2OS_siCtrl
- GSM7709677 U2OS_siCtrl_rep2 U2OS_siCtrl
- GSM7709678 U2OS_siMYBL1_rep1 U2OS_siMYBL1
- GSM7709679 U2OS_siMYBL1_rep2 U2OS_siMYBL1
- GSM7709680 U2OS_siMYBL2_rep1 U2OS_siMYBL2
- GSM7709681 U2OS_siMYBL2_rep2 U2OS_siMYBL2
- GSM7709682 U2OS_siMYBL1-siMYBL2_rep1 U2OS_siMYBL1-siMYBL2
- GSM7709683 U2OS_siMYBL1-siMYBL2_rep2 U2OS_siMYBL1-siMYBL2
- GSE253677 EMILIN1 suppresses cell proliferation by inactivating Aurora Kinase and cell cycle regulator in head and neck squamous cell carcinoma 36 samples shares proliferation, activating, cycle
- GSE314222 Esomeprazole Inhibits Proliferation of Scleroderma Fibroblasts via Cell Cycle Regulation 10 samples shares proliferation, cycle
- GSE273826 Non-catalytic role of SETD1A promotes gastric cancer cell proliferation through the E2F4-TAF6 axis in the cell cycle 30 samples shares proliferation, cycle
- GSE273824 Non-catalytic role of SETD1A promotes gastric cancer cell proliferation through the E2F4-TAF6 axis in the cell cycle (ChIP-seq) 24 samples shares proliferation, cycle
- GSE227973 MY-COMP, an inhibitor of the transcriptional activity of YAP-B-MYB, identifies NEK2 as a novel mediator of YAP oncogenesis in uveal melanoma cells [RNA-seq] 21 samples shares b-myb
- GSE227974 MY-COMP, an inhibitor of the transcriptional activity of YAP-B-MYB, identifies NEK2 as a novel mediator of YAP oncogenesis in uveal melanoma cells 29 samples shares b-myb
- GSE313416 Transient proliferation by reversible YAP- and mitogen-control of the cyclin D1/p27 ratio 63 samples shares proliferation
- GSE299964 Increased LEF1 protein levels and isoform switching drive cell proliferation in chronic lymphocytic leukemia [RNA-Seq] 50 samples shares proliferation
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.