Tumor-associated neutrophils attenuate the immuno-sensitivity of hepatocellular carcinoma and curtail immunotherapy response
RNA-seq (gene expression) · mouse · 23 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 23 samples: 5 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Tumor-associated neutrophils attenuate the immunosensitivity of hepatocellular carcinomaThe Journal of experimental medicine · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE240840_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1005345 and SRA study SRP455012. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 5 replicated groups read from 23 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7710328 Sort-purified SiglecF- TAN, replicate 1 Sort-purified SiglecF- …
- GSM7710329 Sort-purified SiglecF- TAN, replicate 2 Sort-purified SiglecF- …
- GSM7710330 Sort-purified SiglecFhi TAN, replicate 1 Sort-purified SiglecFhi…
- GSM7710331 Sort-purified SiglecFhi TAN, replicate 2 Sort-purified SiglecFhi…
- GSM7710332 No TAN coculture, replicate 1 No TAN coculture,
- GSM7710333 No TAN coculture, replicate 2 No TAN coculture,
- GSM7710334 SiglecF- coculture, replicate 1 SiglecF- coculture,
- GSM7710335 SiglecF- coculture, replicate 2 SiglecF- coculture,
- GSM7710336 SiglecF- coculture, replicate 3 SiglecF- coculture,
- GSM7710337 SiglecFhi coculture, replicate 1 SiglecFhi coculture,
- GSM7710338 SiglecFhi coculture, replicate 2 SiglecFhi coculture,
- GSM7710339 SiglecFhi coculture, replicate 3 SiglecFhi coculture,
- GSM7710340 NRAS/AKT bone marrow, scRNA-seq
- GSM7710341 NRAS/AKT spleen, scRNA-seq
- GSM7710342 NRAS/AKT TIL, Isotype, scRNA-seq
- GSM7710343 NRAS/AKT TIL, anti-Ly6G, scRNA-seq
- GSM8517173 BM neutrophil only
- GSM8517174 BM neutrophil with LA
- GSM8517175 BM neutrophil with GM-CSF
- GSM8517176 BM neutrophil with GM-CSF and LA
- GSM8517177 BM neutrophil with GM-CSF, LA, and 10058-F4
- GSM8517178 NRAS/AKT Tumor, Isotype, scRNA-seq
- GSM8517179 NRAS/AKT Tumor, anti-Ly6G, scRNA-seq
- GSE240838 Tumor-associated neutrophils attenuate the immuno-sensitivity of hepatocellular carcinoma and curtail immunotherapy response [RNA-Seq] 17 samples shares immuno-sensitivity, tumor-associated, hepatocellular, immunotherapy, neutrophils, attenuate, curtail
- GSE263240 Blocking CX3CR1+ Tumor-associated Macrophages Synergize with anti-PD-1 Therapy in Hepatocellular Carcinoma 16 samples shares tumor-associated, hepatocellular
- GSE291357 Short-term starvation boosts anti-PD-L1 therapy by reshaping tumor-associated macrophages in hepatocellular carcinoma 6 samples shares tumor-associated, hepatocellular
- GSE302715 A tumor-associated macrophage-targeted immunocytokine leveraging T and NK cell synergy for potent cancer immunotherapy [scRNA-seq] 187 samples shares tumor-associated, immunotherapy
- GSE212259 Whole-course Taming of Tumor-associated Macrophages from Central to Peripheral using Engineered Outer Membrane Vesicle Nanohybrids for Improved Immunotherapy [part 1: RNA-seq] 36 samples shares tumor-associated, immunotherapy
- GSE290434 A stress response axis in tumor-associated macrophages dictates phenotype heterogeneity and immunotherapy evasion 21 samples shares tumor-associated, immunotherapy
- GSE302836 Loss of Hepatocyte PI3Ka Protects Mice from Hepatocellular Carcinoma in association with altered lipid metabolism gene expression 42 samples shares hepatocellular
- GSE308568 The origin of hepatocellular carcinoma is regulated by metabolic zonation [RNA-seq] 26 samples shares hepatocellular
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.