Phosphorylation controls mRNA retention via nuclear speckle cohesion during environmental perturbations
RNA-seq (gene expression) · human · 79 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 79 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Phosphorylation of a nuclear condensate regulates cohesion and mRNA retentionNature communications · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE240892_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1005649 and SRA study SRP455198. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 79 more — browse all 79 samples with per-sample file links →
- GSE240891 Phosphorylation controls mRNA retention via nuclear speckle cohesion - APEX2-seq 64 samples shares phosphorylation, retention, controls, cohesion, nuclear, speckle
- GSE240883 Phosphorylation controls mRNA retention via nuclear speckle cohesion - cellular fractionation data 15 samples shares phosphorylation, retention, controls, cohesion, nuclear, speckle
- GSE284687 Widespread specific intron-retention events in nuclear RNA complexes identified by sedimentation analysis of pluripotent cellular extracts 63 samples shares retention, nuclear
- GSE292909 Disease-associated loci share features with loci that regulate gene expression in response to environmental perturbations 47 samples shares environmental, perturbations
- GSE299756 LENG8 Functions as a Quality Control Checkpoint for Nuclear Retention and Degradation of Misprocessed RNAs 30 samples shares retention, nuclear
- GSE230508 Nuclear lamin A/C phosphorylation by loss of Androgen Receptor is a global determinant of cancer-associated fibroblast activation 26 samples shares phosphorylation, nuclear
- GSE285137 A phosphorylation switch within the Mediator subunit MED15 controls cellular senescence and cognitive decline [ChIP-seq] 10 samples shares phosphorylation, controls
- GSE262419 Informing Hazard Identification and Risk Characterization of Environmental Chemicals by Combining Transcriptomic and Functional Data from Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes 4558 samples shares environmental
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.