The IL-33/ST2 axis and tissue Treg maintains epithelial homeostasis in the skin and restrains cancer development
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × Wildtype-Naive vs 3 × Wildtype-DMBA vs 3 × TCRbko-DMBA vs 3 × TCRbko---Tregs-DMBAGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE241061_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1006323 and SRA study SRP455561. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7714572 Wildtype-Naive1 Wildtype-Naive
- GSM7714573 Wildtype-Naive2 Wildtype-Naive
- GSM7714574 Wildtype-Naive3 Wildtype-Naive
- GSM7714575 Wildtype-DMBA1 Wildtype-DMBA
- GSM7714576 Wildtype-DMBA2 Wildtype-DMBA
- GSM7714577 Wildtype-DMBA3 Wildtype-DMBA
- GSM7714578 TCRbko-DMBA1 TCRbko-DMBA
- GSM7714579 TCRbko-DMBA2 TCRbko-DMBA
- GSM7714580 TCRbko-DMBA3 TCRbko-DMBA
- GSM7714581 TCRbko---Tregs-DMBA1 TCRbko---Tregs-DMBA
- GSM7714582 TCRbko---Tregs-DMBA2 TCRbko---Tregs-DMBA
- GSM7714583 TCRbko---Tregs-DMBA3 TCRbko---Tregs-DMBA
- GSE305409 Eos maintains Treg homeostasis and plays a critical role in the function of recirculating thymic Tregs [RNA-Seq] 12 samples shares homeostasis, maintains, treg
- GSE314943 Single-cell multiomics uncovers an endothelial mechanosensitive PIEZO1-IL-33 axis driving pulmonary fibrosis 18 samples shares il-33, axis
- GSE326488 Ubiquitin-like proteins NEDD8 and SUMO2 control epithelial homeostasis, regeneration, and inflammation [RNA-Seq mouse] 14 samples shares homeostasis, epithelial
- GSE287897 SPT6 maintains epidermal homeostasis by inhibiting an NF-κB- positive feedback loop to prevent excessive inflammation 9 samples shares homeostasis, maintains
- GSE326641 Ubiquitin-like proteins NEDD8 and SUMO2 control epithelial homeostasis, regeneration, and inflammation [scRNA-seq] 8 samples shares homeostasis, epithelial
- GSE291449 T cell receptor signaling induces expression of lysine demethylase KDM6B to maintain Treg homeostasis 46 samples shares homeostasis, treg
- GSE268774 Lymph node macrophages drive immune tolerance and resistance to cancer therapy by expression of the immune-regulatory cytokine IL-33 [RNA-seq] 48 samples shares il-33
- GSE261940 Soluble ST2 induces cardiac contractile dysfunction by repressing mitochondrial electron transport chain genes in cardiomyocytes during fulminant myocarditis 20 samples shares st2
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.