Eos maintains Treg homeostasis and plays a critical role in the function of recirculating thymic Tregs [RNA-Seq]
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 4 × Eosplus Treg vs 4 × Eosminus Treg vs 4 × TconvGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Eos plays a critical role in Treg homeostasis and modulates the function of recirculating thymic Tregs in the control of Treg developmentCell reports · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE305409_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1305478 and SRA study SRP608740. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 3 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9176666 Eosplus Treg Rep1 Eosplus Treg
- GSM9176667 Eosminus Treg Rep1 Eosminus Treg
- GSM9176668 Tconv Rep1 Tconv
- GSM9176669 Eosplus Treg Rep2 Eosplus Treg
- GSM9176670 Eosminus Treg Rep2 Eosminus Treg
- GSM9176671 Tconv Rep2 Tconv
- GSM9176672 Eosplus Treg Rep3 Eosplus Treg
- GSM9176673 Eosminus Treg Rep3 Eosminus Treg
- GSM9176674 Tconv Rep3 Tconv
- GSM9176675 Eosplus Treg Rep4 Eosplus Treg
- GSM9176676 Eosminus Treg Rep4 Eosminus Treg
- GSM9176677 Tconv Rep4 Tconv
- GSE296482 A cell-intrinsic glucocorticoid biosynthesis and sensing circuit maintains homeostatic Th17 cell state [RNA-seq] 31 samples shares maintains, rna-seq
- GSE244619 ZFP36-family RNA-binding proteins in regulatory T cells reinforce immune homeostasis [bulk RNA-seq] 24 samples shares homeostasis, rna-seq
- GSE263342 CNOT3 maintains ILC2 integrity by destabilizing Tbx21 and Rorc mRNAs [RNA-seq] 24 samples shares maintains, rna-seq
- GSE291118 Macropinocytosis maintains CAF subtype identity under metabolic stress in pancreatic cancer [RNA-seq] 20 samples shares maintains, rna-seq
- GSE225414 Mitochondrial regulation of bone homeostasis via mitochondria transfer [RNA-seq] 18 samples shares homeostasis, rna-seq
- GSE326488 Ubiquitin-like proteins NEDD8 and SUMO2 control epithelial homeostasis, regeneration, and inflammation [RNA-Seq mouse] 14 samples shares homeostasis, rna-seq
- GSE336280 Murine pancreatic tumors induce pathological remodeling of muscles critical to chewing and swallowing [RNA-seq] 13 samples shares critical, rna-seq
- GSE238201 Loss of PPARα function promotes epigenetic dysregulation of lipid homeostasis driving ferroptosis and pyroptosis lipotoxicity in Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD) [RNA-seq] 12 samples shares homeostasis, rna-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.