Soluble ST2 induces cardiac contractile dysfunction by repressing mitochondrial electron transport chain genes in cardiomyocytes during fulminant myocarditis
RNA-seq (gene expression) · mouse · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 20 samples: 7 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE261940_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1089611 and SRA study SRP496473. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 20 samples.
How we read this: 7 replicated groups read from 20 sample titles; they account for 20 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8154888 Heart,Control,rep1 Heart,Control,
- GSM8154889 Heart,Control,rep2 Heart,Control,
- GSM8154890 Heart,CVB3,rep1 Heart,CVB3,
- GSM8154891 Heart,CVB3,rep2 Heart,CVB3,
- GSM8154892 Heart,CVB3 and ST2, rep1 Heart,CVB3 and ST2,
- GSM8154893 Heart,CVB3 and ST2, rep2 Heart,CVB3 and ST2,
- GSM8154894 Heart,CVB3 and ST2, rep3 Heart,CVB3 and ST2,
- GSM8154895 NMCM, Control,rep1 NMCM, Control,
- GSM8154896 NMCM, Control,rep2 NMCM, Control,
- GSM8154897 NMCM, Control,rep3 NMCM, Control,
- GSM8154898 NMCM, Control,rep4 NMCM, Control,
- GSM8154899 NMCM, sST2, rep1 NMCM, sST2,
- GSM8154900 NMCM, sST2, rep2 NMCM, sST2,
- GSM8154901 NMCM, sST2, rep3 NMCM, sST2,
- GSM8154902 NMCM, sST2, rep4 NMCM, sST2,
- GSM8154903 NMCM, CVB3,rep1 NMCM, CVB3,
- GSM8154904 NMCM, CVB3,rep2 NMCM, CVB3,
- GSM8154905 NMCM, CVB3 and ST2，rep1 NMCM, CVB3 and ST2，
- GSM8154906 NMCM, CVB3 and ST2，rep2 NMCM, CVB3 and ST2，
- GSM8154907 NMCM, CVB3 and ST2，rep3 NMCM, CVB3 and ST2，
- GSE280991 Partial restoration of the mitochondrial dysfunction by AAV-Ant1 (Slc25a4) transduction protects against dilated cardiomyopathy in Slc25a4-/- plus mtDNA mutant mice 115 samples shares mitochondrial, dysfunction
- GSE280273 A multi-omics census reveals miRNA miR-let-7 as instigator of paternal mitochondrial dysfunction and in epigenetic heredity of intergenerational metabolic decline [F0_Liv_eWAT_RNAseq] 36 samples shares mitochondrial, dysfunction
- GSE293219 Adipocyte-specific Mlkl knockout mitigates obesity-induced metabolic dysfunction by enhancing mitochondrial functions. 36 samples shares mitochondrial, dysfunction
- GSE300519 Neurotoxicity, α-Synuclein Pathology, and Mitochondrial Dysfunction: A Comparative Study of Three Parkinson’s Disease Mouse Models 35 samples shares mitochondrial, dysfunction
- GSE291086 Neuronal ABCA7 deficiency aggravates mitochondrial dysfunction and neurodegeneration in Alzheimer’s disease 24 samples shares mitochondrial, dysfunction
- GSE276978 LOXL2 protects temporomandibular joint from mitochondrial dysfunction, apoptosis and osteoarthritis like progression 20 samples shares mitochondrial, dysfunction
- GSE291363 Mitochondrial dysfunction charachterizes the multigenerational effects of maternal obesity on MASLD 18 samples shares mitochondrial, dysfunction
- GSE271207 2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction 16 samples shares mitochondrial, dysfunction
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.