Role of reducing Hmbox1 in cardiac ischemia/reperfusion injury
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × Con_Sham vs 3 × shHmbox1_Sham vs 3 × Con_IRI vs 3 × shHmbox1_IRIGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Inhibition of Hmbox1 Promotes Cardiomyocyte Survival and Glucose Metabolism Through Gck Activation in Ischemia/Reperfusion InjuryCirculation · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE241079_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1006367 and SRA study SRP455648. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7714858 Con_Sham_1 Con_Sham
- GSM7714859 Con_Sham_2 Con_Sham
- GSM7714860 Con_Sham_3 Con_Sham
- GSM7714861 shHmbox1_Sham_1 shHmbox1_Sham
- GSM7714862 shHmbox1_Sham_2 shHmbox1_Sham
- GSM7714863 shHmbox1_Sham_3 shHmbox1_Sham
- GSM7714864 Con_IRI_1 Con_IRI
- GSM7714865 Con_IRI_2 Con_IRI
- GSM7714866 Con_IRI_3 Con_IRI
- GSM7714867 shHmbox1_IRI_1 shHmbox1_IRI
- GSM7714868 shHmbox1_IRI_2 shHmbox1_IRI
- GSM7714869 shHmbox1_IRI_3 shHmbox1_IRI
- GSE260488 Hypidonehydrochloride (YL-0919) improves MCAO-induced ischemia-reperfusion injury by reducing inflammation 9 samples shares reperfusion, reducing, ischemia, injury
- GSE245988 Vascular endothelial S1PR2 aggravates cardiac ischemia/reperfusion injury through triggering mitochondrial dysfunctions and endothelial pyroptosis via RHO/ROCK1/DRP1/NLRP3 pathway [endothelial cells] 6 samples shares reperfusion, ischemia, cardiac, injury
- GSE245987 Vascular endothelial S1PR2 aggravates cardiac ischemia/reperfusion injury through triggering mitochondrial dysfunctions and endothelial pyroptosis via RHO/ROCK1/DRP1/NLRP3 pathway [heart] 4 samples shares reperfusion, ischemia, cardiac, injury
- GSE281940 Role of KLF5 in Ischemia Reperfusion Injury 12 samples shares reperfusion, ischemia, injury
- GSE267650 Mouse kidney ischemia-reperfusion injury time course 57 samples shares reperfusion, ischemia, injury
- GSE294969 Enhanced Expression of the Female-Biased Gene Gsta2 in Male Proximal Tubule Cells Improves Renal Resilience to Ischemia-Reperfusion Injury 30 samples shares reperfusion, ischemia, injury
- GSE254747 ZBP1-mediated apoptosis and inflammation exacerbate steatotic liver ischemia/reperfusion injury 18 samples shares reperfusion, ischemia, injury
- GSE302628 Evaluation of the pharmacological effects of oridonin on hepatic ischemia/reperfusion injury in vivo 18 samples shares reperfusion, ischemia, injury
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.