GEO series
Evaluation of the pharmacological effects of oridonin on hepatic ischemia/reperfusion injury in vivo
GSE302628
Mus musculus
Expression profiling by high throughput sequencing
18 samples
2025/10/20
GPL24247
Summary
The study aims to explore the protective effects of oridonin against hepatic ischemia–reperfusion injury (IRI) and its underlying mechanisms. Hepatic IRI is a significant clinical issue that can lead to severe liver dysfunction. Oridonin (Ori), a natural diterpenoid compound, has shown promising therapeutic potential. In an in vivo model of hepatic IRI, oridonin (5 mg/kg) treatment significantly reduced serum levels of liver injury markers. In this study, we comprehensively investigated the pharmacological effects of oridonin in the treatment of liver IRI and clarified the potential molecular mechanisms.
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