GEO series
Enhanced Expression of the Female-Biased Gene Gsta2 in Male Proximal Tubule Cells Improves Renal Resilience to Ischemia-Reperfusion Injury
GSE294969
Mus musculus
Expression profiling by high throughput sequencing
30 samples
2025/09/30
GPL24247
Summary
Background: Genetic sex is an important determinant of renal injury and repair, with female kidneys typically exhibiting greater resilience to acute kidney injury (AKI). Among the sexually dimorphic genes in mouse proximal tubule cells (PTCs), Gsta2, an NRF2-regulated antioxidant enzyme, is strongly enriched in females. Here, we hypothesized that augmenting Gsta2 in male PTCs would enhance resistance to ischemia-reperfusion injury (IRI).
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