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Effect of BMP4 overexpression in MycCaP cells on TAMs in ostegenic prostate tumors

GSE241344 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2024/09/08 Platform GPL21626
Summary
Tumor-associated macrophages (TAMs) play an important role in cancer progression and have been implicated to play a role in prostate cancer. However, TAMs in osteogenic prostate cancer bone metastasis have not been characterized. Here we used a novel osteogenic MycCaP-BMP4 model to study the unique cellular and molecular mechanisms in driving the tumor progression in osteogenic prostate cancer metastasis.
Published in
Prostate cancer-induced endothelial-cell-to-osteoblast transition drives immunosuppression in the bone-tumor microenvironment through Wnt pathway-induced M2 macrophage polarization
Yu G, Corn PG, Mak CSL et al. · Proceedings of the National Academy of Sciences of the United States of America 2024 · PMID 39102549 · doi:10.1073/pnas.2402903121
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Also filed as BioProject PRJNA1007725 and SRA study SRP456223. Searching any of these in the dataset finder brings you back here.

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