SARS-CoV-2 spike protein induces the cytokine release syndrome by stimulating T cells to produce more IL-2
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 12 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- SARS-CoV-2 spike protein induces the cytokine release syndrome by stimulating T cells to produce more IL-2Frontiers in immunology · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE241843_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1010223 and SRA study SRP457360. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 12 sample titles: 12 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7744335 biol rep 1, Donor 1, PBMCs, Control
- GSM7744336 biol rep 1, Donor 1, PBMCs, Spike protein
- GSM7744337 biol rep 1, Donor 1, PBMCs, IL-2
- GSM7744338 biol rep 1, Donor 1, PBMCs, Spike protein+IL-2
- GSM7744339 biol rep 2, Donor 2, PBMCs, Control
- GSM7744340 biol rep 2, Donor 2, PBMCs, Spike protein
- GSM7744341 biol rep 2, Donor 2, PBMCs, IL-2
- GSM7744342 biol rep 2, Donor 2, PBMCs, Spike protein+IL-2
- GSM7744343 biol rep 3, Donor 3, PBMCs, Control
- GSM7744344 biol rep 3, Donor 3, PBMCs, Spike protein
- GSM7744345 biol rep 3, Donor 3, PBMCs, IL-2
- GSM7744346 biol rep 3, Donor 3, PBMCs, Spike protein+IL-2
- GSE269112 Notch induces transcription by stimulating release of paused RNA Pol II without increasing chromatin accessibility [ATAC-seq] 28 samples shares stimulating, induces, release
- GSE276544 MVA-based SARS-CoV-2 vaccine candidates encoding different spike protein conformations induce distinct early transcriptional responses which may impact subsequent adaptive immunity 305 samples shares sars-cov-2, protein
- GSE311760 IL-22 induces Paneth cell metaplasia in the colonic epithelium of ulcerative colitis, promoting wound healing via REG3A 18 samples shares il-2, induces
- GSE327545 SARS-CoV-2 nucleocapsid induces hyperinflammation and vascular leakage through the Toll-like receptor signaling axis in macrophages 16 samples shares sars-cov-2, induces
- GSE304122 Th17 Cells with Regulatory Phenotype are the Main IL-17F and IL-26 Producers in Palmoplantar Pustulosis 10 samples shares il-2, produce
- GSE303680 PD1-targeted cis-delivery of an IL-2 variant induces a multifaceted anti-tumoral T cell response in human lung cancer 10 samples shares il-2, induces
- GSE227098 IL-21 induces antitumor response in NK cells via CEBPD 60 samples shares il-2, induces
- GSE272396 Endogenously produced itaconate negatively regulates innate-driven cytokine production and drives global ubiquitination in human macrophages 36 samples shares cytokine, produce
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.