A molecular atlas of brain neurovascular interactions reveals a spatiotemporal requirement of TGFβ signaling in brain angiogenesis
RNA-seq (gene expression) · mouse · 13 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 13 samples: 2 × Visium_P6_Brain_WT vs 2 × Visium_P12_Brain_WT vs 2 × FLEX-Pool1-P vs 2 × Visium_P60_Brain_WTGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Mapping neuro-vascular unit communications reveals distinct angiogenic programs across developing mouse brain regionsNature communications · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE242215_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1011998 and SRA study SRP458068. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 8 samples.
How we read this: 4 replicated groups read from 13 sample titles; they account for 8 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7755666 scRNAseq_P12_Brain_WT_AB
- GSM7755667 scRNAseq_P12_Brain_WT_IJ
- GSM7755668 scRNAseq_P12_Brain_Alk5iEKO_EF
- GSM7755669 scRNAseq_P12_Brain_Alk5iEKO_KL
- GSM7755670 Visium_P6_Brain_WT Visium_P6_Brain_WT
- GSM7755671 Visium_P12_Brain_WT Visium_P12_Brain_WT
- GSM9401502 FLEX-Pool1-P6 FLEX-Pool1-P
- GSM9401503 FLEX-Pool1-P12 FLEX-Pool1-P
- GSM9401504 FLEX-Pool2-Adult
- GSM9405376 Visium_P6_Brain_WT_rep2 Visium_P6_Brain_WT
- GSM9405377 Visium_P12_Brain_WT_rep2 Visium_P12_Brain_WT
- GSM9405378 Visium_P60_Brain_WT_rep1 Visium_P60_Brain_WT
- GSM9405379 Visium_P60_Brain_WT_rep2 Visium_P60_Brain_WT
- GSE233815 Spatiotemporal transcriptomic map of glial cell response in a mouse model of acute brain ischemia 61 samples shares spatiotemporal, brain
- GSE254164 Dynamic fibroblast-immune interactions shape recovery after brain injury 26 samples shares interactions, brain
- GSE341480 Spatiotemporal Clonal Architecture of the Newborn Mouse Forebrain 186 samples shares spatiotemporal, brain
- GSE252621 Interactions of Polychlorinated Biphenyls and Their Metabolites with the Brain and Liver Transcriptome of Female Mice 62 samples shares interactions, brain
- GSE233811 Spatiotemporal transcriptomic map of glial cell response in a mouse model of acute brain ischemia [bulk RNA-Seq] 48 samples shares spatiotemporal, brain
- GSE325187 Senescent Endothelial Cells in Cerebral Microcirculation Are Key Drivers of Age-Related Blood-Brain Barrier Disruption, Microvascular Rarefaction, and Neurovascular Coupling Impairment in Mice 20 samples shares neurovascular, brain
- GSE254162 Dynamic fibroblast-immune interactions shape recovery after brain injury [snRNASeq_Timecourse] 12 samples shares interactions, brain
- GSE293493 Transcriptional effects of co-culture on the spatiotemporal dynamics of T cell motility and cancer-T cell interactions [bulk_seq_IFN] 10 samples shares spatiotemporal, interactions
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.