The protective effect of LCN2 knockout on the imiquimod-induced psoriatic mouse model
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × WT-Control vs 3 × WT-IMQ vs 3 × LCN2 KO-Control vs 3 × LCN2 KO-IMQGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Synergistic effects of LCN2 and TWEAK on the progression of psoriasisCellular & molecular immunology · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE242420_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1013395 and SRA study SRP458757. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7763383 WT-Control 1 WT-Control
- GSM7763384 WT-Control 2 WT-Control
- GSM7763385 WT-Control 3 WT-Control
- GSM7763386 WT-IMQ 1 WT-IMQ
- GSM7763387 WT-IMQ 2 WT-IMQ
- GSM7763388 WT-IMQ 3 WT-IMQ
- GSM7763389 LCN2 KO-Control 1 LCN2 KO-Control
- GSM7763390 LCN2 KO-Control 2 LCN2 KO-Control
- GSM7763391 LCN2 KO-Control 3 LCN2 KO-Control
- GSM7763392 LCN2 KO-IMQ 1 LCN2 KO-IMQ
- GSM7763393 LCN2 KO-IMQ 2 LCN2 KO-IMQ
- GSM7763394 LCN2 KO-IMQ 3 LCN2 KO-IMQ
- GSE303157 Lcn2 deficiency leads to social impairments independent of maternal immune activation 18 samples shares lcn2
- GSE269493 Hepatoprotective effects of late-stage clinical drug candidates and dietary intervention in the non-obese CDAA-HFD mouse model of advanced MASH with progressive fibrosis 81 samples shares protective
- GSE268757 Reproducible lung protective effects of a TGFβR1/ALK5 inhibitor in the bleomycin-induced and spirometry-confirmed mouse model of IPF 75 samples shares protective
- GSE263273 Increased hepatoprotective effects of the novel farnesoid X receptor agonist INT-787 versus obeticholic acid in a mouse model of nonalcoholic steatohepatitis 28 samples shares protective
- GSE288054 Protective effects of two different chaperones demonstrated in a mouse model of sporadic AD 20 samples shares protective
- GSE223376 TMEM106B coding variant is protective and deletion detrimental in a mouse model of tauopathy 72 samples shares protective
- GSE274859 Differential neuroprotective and anti-inflammatory effects of dimethyl fumarate, monomethyl fumarate and cannabidiol in neurons and microglia [Mouse] 36 samples shares protective
- GSE225899 Protective effects on melphalan-induced mouse intestinal injury treated by Human Umbilical Cord-derived Mesenchymal Stem Cells 12 samples shares protective
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.