Atf3 controls transitioning in female mitochondrial cardiomyopathy as identified by single-cell transcriptomics
Single-cell RNA-seq · human · 26 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart.
- Organism
- Homo sapiens (human)
- Samples
- 26 samples: 25 distinct titles, 1 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Atf3 controls transitioning in female mitochondrial cardiomyopathy as identified by spatial and single-cell transcriptomicsScience advances · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE242821_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1014902 and SRA study SRP459526. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 26 sample titles: 25 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7771464 Atf3_high, replicate 1, PIC
- GSM7771465 Atf3_high, replicate 2, PIC
- GSM7771466 Atf3_high, replicate 3, PIC
- GSM7771467 Atf3_low, replicate 1, PIC
- GSM7771468 Atf3_low, replicate 2, PIC
- GSM7771469 Atf3_low, replicate 3, PIC
- GSM7771470 MyoAAV2-shCtrl, replicate1, RNA-seq
- GSM7771471 MyoAAV2-shCtrl, replicate2, RNA-seq
- GSM7771472 MyoAAV2-shCtrl, replicate3, RNA-seq
- GSM7771473 MyoAAV2-shAtf3, replicate1, RNA-seq
- GSM7771474 MyoAAV2-shAtf3, replicate2, RNA-seq
- GSM7771475 MyoAAV2-shAtf3, replicate3, RNA-seq
- GSM7771476 Atf3+/+FS6KD, replicate1, RNA-seq
- GSM7771477 Atf3+/+FS6KD, replicate2, RNA-seq
- GSM7771478 Atf3+/+FS6KD, replicate3, RNA-seq
- GSM7771479 Atf3+/+FS6KD, replicate4, RNA-seq
- GSM7771480 Atf3-/-FS6KD, replicate1, RNA-seq
- GSM7771481 Atf3-/-FS6KD, replicate2, RNA-seq
- GSM7771482 Atf3-/-FS6KD, replicate3, RNA-seq
- GSM7771483 Atf3-/-FS6KD, replicate4, RNA-seq
- GSM7771484 FS6WT, 8 weeks, scRNAseq
- GSM7771485 FS6KD, 8 weeks, scRNAseq
- GSM7771486 FS6KD, 12 weeks, scRNAseq
- GSM7771487 FS6KD, 17 weeks, scRNAseq
- GSM7771488 MCM, scRNAseq
- GSM8647873 MCM, scRNAseq
- GSE242820 Atf3 controls transitioning in female mitochondrial cardiomyopathy as identified by single-cell transcriptomics [snRNA-seq] 5 samples shares atf3, cardiomyopathy, transitioning, mitochondrial, single-cell, identified, controls, female
- GSE239815 Epigenetic inheritance of diet-induced and sperm-borne mitochondrial RNAs 307 samples shares mitochondrial
- GSE342640 Insulin resistance is associated with mammary mitochondrial dysfunction at the onset of human lactation 159 samples shares mitochondrial
- GSE293066 MAVS Orchestrates a Potent IFN-independent Antiviral Immunity by 2 Preserving Mitochondrial Integrity 54 samples shares mitochondrial
- GSE271871 A leiomodin 2 neonatal dilated cardiomyopathy causing mutation results inaltered actin-regulatory gene signatures andcardiomyocyte dysfunction 42 samples shares cardiomyopathy
- GSE310202 Linezolid prevents fibroblast activation and ameliorates tissue fibrosis by inhibition of mitochondrial translation 36 samples shares mitochondrial
- GSE103550 Lung Cancer Cell-Mediated Skeletal Muscle Mitochondrial Dysfunction is Mitigated by 1a,25-Dihydroxyvitamin D3 24 samples shares mitochondrial
- GSE330200 The p.Ser143Pro lamin A/C mutation leads to dilated cardiomyopathy and activates the unfolded protein response pathway in a knock-in mouse model 19 samples shares cardiomyopathy
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.