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Mitotic endosomes regulate spindle organization and function via Occludin and FIP5 binding

GSE242842 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/09/11 Platform GPL24247
Summary
The genetic basis of vertebrate emergence is a major unanswered question in metazoan evolution. Understanding vertebrate-specific genes, such as Occludin (Ocln), may help answer this question. Here, we show that mammary glands lacking Ocln exhibit retarded branching, resulting from reduced cell proliferation. Interestingly, Ocln regulates spindle orientation and function, and its loss leads to a range of phenotypes, including prolonged prophase and failed nuclear and/or cytoplasmic division.
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Also filed as BioProject PRJNA1015131 and SRA study SRP459695. Searching any of these in the dataset finder brings you back here.

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