EWSR1::FLI1 fusion oncoproteins’ regulation of ETS1 (CUT&RUN)
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 14 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 14 samples: 7 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- ETS1, a Target Gene of the EWSR1::FLI1 Fusion Oncoprotein, Regulates the Expression of the Focal Adhesion Protein TENSIN3Molecular cancer research : MCR · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE243277_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1017516 and SRA study SRP460676. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 14 samples.
How we read this: 7 replicated groups read from 14 sample titles; they account for 14 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7782750 TC-32 WT, A, IgG, rep 1 TC-32 WT, A, IgG,
- GSM7782751 TC-32 WT, A, IgG, rep 2 TC-32 WT, A, IgG,
- GSM7782752 TC-32 WT, A, FLI1, rep 1 TC-32 WT, A, FLI1,
- GSM7782753 TC-32 WT, A, FLI1, rep 2 TC-32 WT, A, FLI1,
- GSM7782754 TC-32 WT, A, H3K27ac, rep 1 TC-32 WT, A, H3K27ac,
- GSM7782755 TC-32 WT, A, H3K27ac, rep 2 TC-32 WT, A, H3K27ac,
- GSM7782756 TC-32 WT, B, IgG, rep 1 TC-32 WT, B, IgG,
- GSM7782757 TC-32 WT, B, IgG, rep 2 TC-32 WT, B, IgG,
- GSM7782758 TC-32 WT, B, FLI1, rep 1 TC-32 WT, B, FLI1,
- GSM7782759 TC-32 WT, B, FLI1, rep 2 TC-32 WT, B, FLI1,
- GSM7782760 TC-32 WT, B, H3K9me3, rep 1 TC-32 WT, B, H3K9me3,
- GSM7782761 TC-32 WT, B, H3K9me3, rep 2 TC-32 WT, B, H3K9me3,
- GSM7782762 TC-32 WT, B, H3K27me3, rep 1 TC-32 WT, B, H3K27me3,
- GSM7782763 TC-32 WT, B, H3K27me3, rep 2 TC-32 WT, B, H3K27me3,
- GSE303343 A unified network systems approach uncovers a core program underlying T follicular helper cell differentiation [CUT&RUN] 48 samples shares cut, run
- GSE334008 CTCF regulates wild-type and recombinant AAV gene expression by shaping viral chromatin [CUT&Run] 47 samples shares cut, run
- GSE287902 BPTF regulstes androgen receptor activity by enhancing chromatin accessibility and stabilizing the AR-FOXA1 interaction [Cut&Run] 40 samples shares cut, run
- GSE269555 Targeting the oncohistone-ASCL1 axis disrupts plasticity and suppresses pediatric gliomas [CUT&RUN] 39 samples shares cut, run
- GSE278910 Pooled CRISPR screens with joint single-nucleus chromatin accessibility and transcriptome profiling [CUT&RUN] 30 samples shares cut, run
- GSE301512 Chromatin topology dynamics of dexamethasone-treated trabecular meshwork identifies 78 causal genes for intraocular pressure and primary open angle glaucoma [CUT&Run] 30 samples shares cut, run
- GSE253893 PAX translocations remodel mitochondrial metabolism through altered leucine usage in rhabdomyosarcoma [Cut&Run] 28 samples shares cut, run
- GSE267470 Dual targeting of processive transcription for Myc-driven circuitry in medulloblastoma [CUT&RUN] 12 samples shares cut, run
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.