Human Brain Small Extracellular Vesicles Contain Selectively-Packaged, Full-Length mRNA
RNA-seq (gene expression) · mouse · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 18 samples: 6 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Human brain small extracellular vesicles contain selectively packaged, full-length mRNACell reports · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE243611_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1019233 and SRA study SRP462028. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 18 samples.
How we read this: 6 replicated groups read from 18 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7791853 Primary mouse astrocytes rep1 Primary mouse astrocytes
- GSM7791854 Primary mouse astrocyte-derived sEVs rep1 Primary mouse astrocyte…
- GSM7791855 Primary mouse astrocytes rep2 Primary mouse astrocytes
- GSM7791856 Primary mouse astrocyte-derived sEVs rep2 Primary mouse astrocyte…
- GSM7791857 Primary mouse astrocytes rep3 Primary mouse astrocytes
- GSM7791858 Primary mouse astrocyte-derived sEVs rep3 Primary mouse astrocyte…
- GSM7791859 Primary mouse microglia rep1 Primary mouse microglia
- GSM7791860 Primary mouse microglia-derived sEVs rep1 Primary mouse microglia…
- GSM7791861 Primary mouse microglia rep2 Primary mouse microglia
- GSM7791862 Primary mouse microglia-derived sEVs rep2 Primary mouse microglia…
- GSM7791863 Primary mouse microglia rep3 Primary mouse microglia
- GSM7791864 Primary mouse microglia-derived sEVs rep3 Primary mouse microglia…
- GSM7791865 Primary mouse neurons rep1 Primary mouse neurons
- GSM7791866 Primary mouse neuron-derived sEVs rep1 Primary mouse neuron-de…
- GSM7791867 Primary mouse neurons rep2 Primary mouse neurons
- GSM7791868 Primary mouse neuron-derived sEVs rep2 Primary mouse neuron-de…
- GSM7791869 Primary mouse neurons rep3 Primary mouse neurons
- GSM7791870 Primary mouse neuron-derived sEVs rep3 Primary mouse neuron-de…
- GSE201969 In vivo self-assembly and targeted delivery of EGFR siRNA-encapsulating small extracellular vesicles to EGFR-positive cancer cells for NSCLC therapy 72 samples shares extracellular, vesicles, small
- GSE220060 Total RNA expression in mouse heart tissues after injections of VEGFA-containing extracellular vessicle, lipidnanoparticles and naked-VEGFA mRNA 18 samples shares extracellular, contain, mrna
- GSE333191 Integration of Transcriptional Signatures from Brain Tissue and Plasma Extracellular Vesicles of a Preclinical Tauopathy Mouse Model 16 samples shares extracellular, vesicles, brain
- GSE278553 Toxoplasma gondii infection of neurons alters the production and content of extracellular vesicles directing astrocyte phenotype and contributing to the loss of GLT-1 in the infected brain 15 samples shares extracellular, vesicles, brain
- GSE327585 Status Epilepticus Alters the Function of Brain-Derived Extracellular Vesicles [N2A-RNA-Seq] 12 samples shares extracellular, vesicles, brain
- GSE327586 Status Epilepticus Alters the Function of Brain-Derived Extracellular Vesicles [BV2-RNA-seq] 9 samples shares extracellular, vesicles, brain
- GSE242731 Class switch recombination regulation by extracellular vesicles mediated intercellular epigenomic signaling 48 samples shares extracellular, vesicles
- GSE240538 A bone regenerative strategy based on extracellular vesicles transporting citrate for promoting biomineralization 37 samples shares extracellular, vesicles
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.