RNA Seq of hearts upon hepatocyte-specific overexpression of REV-ERBα in cancer cachexia
RNA-seq (gene expression) · mouse · 29 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 29 samples: 10 × C26_GFP vs 10 × C26_REV-ERBa vs 5 × PBS_REV-ERBa vs 4 × PBS_GFPGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Functional liver genomics identifies hepatokines promoting wasting in cancer cachexiaCell · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE293093_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1242787 and SRA study SRP573608. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 29 samples.
How we read this: 4 replicated groups read from 29 sample titles; they account for 29 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8876018 PBS_GFP_Rep_1 PBS_GFP
- GSM8876019 PBS_GFP_Rep_2 PBS_GFP
- GSM8876020 PBS_GFP_Rep_3 PBS_GFP
- GSM8876021 PBS_GFP_Rep_4 PBS_GFP
- GSM8876022 PBS_REV-ERBa_Rep_1 PBS_REV-ERBa
- GSM8876023 PBS_REV-ERBa_Rep_2 PBS_REV-ERBa
- GSM8876024 PBS_REV-ERBa_Rep_3 PBS_REV-ERBa
- GSM8876025 PBS_REV-ERBa_Rep_4 PBS_REV-ERBa
- GSM8876026 PBS_REV-ERBa_Rep_5 PBS_REV-ERBa
- GSM8876027 C26_GFP_Rep_1 C26_GFP
- GSM8876028 C26_GFP_Rep_2 C26_GFP
- GSM8876029 C26_GFP_Rep_3 C26_GFP
- GSM8876030 C26_GFP_Rep_4 C26_GFP
- GSM8876031 C26_GFP_Rep_5 C26_GFP
- GSM8876032 C26_GFP_Rep_6 C26_GFP
- GSM8876033 C26_GFP_Rep_7 C26_GFP
- GSM8876034 C26_GFP_Rep_8 C26_GFP
- GSM8876035 C26_GFP_Rep_9 C26_GFP
- GSM8876036 C26_GFP_Rep_10 C26_GFP
- GSM8876037 C26_REV-ERBa_Rep_1 C26_REV-ERBa
- GSM8876038 C26_REV-ERBa_Rep_2 C26_REV-ERBa
- GSM8876039 C26_REV-ERBa_Rep_3 C26_REV-ERBa
- GSM8876040 C26_REV-ERBa_Rep_4 C26_REV-ERBa
- GSM8876041 C26_REV-ERBa_Rep_5 C26_REV-ERBa
- GSM8876042 C26_REV-ERBa_Rep_6 C26_REV-ERBa
- GSM8876043 C26_REV-ERBa_Rep_7 C26_REV-ERBa
- GSM8876044 C26_REV-ERBa_Rep_8 C26_REV-ERBa
- GSM8876045 C26_REV-ERBa_Rep_9 C26_REV-ERBa
- GSM8876046 C26_REV-ERBa_Rep_10 C26_REV-ERBa
- GSE273879 Cancer-induced FOXP1 disrupts and reprograms skeletal muscle circadian transcription in cachexia [skeletal muscle overexpression of FoxP1 RNA-seq] 10 samples shares overexpression, cachexia
- GSE244213 Liver transcriptomic profile of 6 months old wild type and hepatocyte-specific ATF6 overexpression mice 13 samples shares hepatocyte-specific, overexpression
- GSE244212 Liver transcriptomic profile of 3 months old wild type and hepatocyte-specific ATF6 overexpression mice 12 samples shares hepatocyte-specific, overexpression
- GSE275001 Methionine cycle dysregulation mediates REDD1 overexpression-induced muscle atrophy in cancer cachexia 12 samples shares overexpression, cachexia
- GSE312483 Targeting metabolic vulnerabilities: REV-ERB agonist SR9009 potentiates sorafenib efficacy in liver cancer 15 samples shares rev-erb
- GSE267792 Transcriptional characterization of ILC1 and different subsets of ILC3s lacking REV-ERBs. 30 samples shares rev-erb
- GSE317634 Negative regulation of TH17-mediated inflammation by the nuclear receptor REV-ERBβ 26 samples shares rev-erb
- GSE293026 REV-ERB-alpha and -beta coordinately regulate astrocyte reactivity and proteostatic function 26 samples shares rev-erb
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.