Liver transcriptomic profile of 6 months old wild type and hepatocyte-specific ATF6 overexpression mice
RNA-seq (gene expression) · mouse · 13 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 13 samples: 7 × Tg vs 6 × WTGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Activated ATF6α is a hepatic tumour driver restricting immunosurveillanceNature · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE244213_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1021675 and SRA study SRP463559. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 13 samples.
How we read this: 2 replicated groups read from 13 sample titles; they account for 13 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7808725 WT_16151 WT
- GSM7808726 WT_21295 WT
- GSM7808727 WT_21296 WT
- GSM7808728 WT_21297 WT
- GSM7808729 WT_22003 WT
- GSM7808730 WT_22009 WT
- GSM7808731 Tg_16152 Tg
- GSM7808732 Tg_16153 Tg
- GSM7808733 Tg_16154 Tg
- GSM7808734 Tg_16155 Tg
- GSM7808735 Tg_16156 Tg
- GSM7808736 Tg_21298 Tg
- GSM7808737 Tg_22002 Tg
- GSE244212 Liver transcriptomic profile of 3 months old wild type and hepatocyte-specific ATF6 overexpression mice 12 samples shares atf6, hepatocyte-specific, overexpression, months, liver, wild, type
- GSE285265 Liver transcriptomic profile of wild type and hepatocyte-specific ATF6 knockout mice feeding CD-HFD 11 samples shares atf6, hepatocyte-specific, liver, wild, type
- GSE293041 Single-cell transcriptome analysis of wildtype, TREM2 knockout, GPR34 knock-out or TREM2/GPR34 double knock-out primary microglia from wildtype and APP knock-in mice (8 months) 10 samples shares months, wild, type
- GSE339349 Physiological YAP activation alleviate ER stress to mitigate alcohol-induced liver damage by promoting ATF6 transcriptional activation 18 samples shares atf6, liver
- GSE223049 Bulk RNA-seq in young (2 months) and aged (22-24 months) mice across 23 cell-types 170 samples shares months, type
- GSE309118 Hepatocyte-specific epidermal growth factor receptor (EGFR) deletion attenuates acetaminophen-induced liver injury in mice 42 samples shares hepatocyte-specific, liver
- GSE283998 MBNL overexpression rescues cardiac phenotypes in a myotonic dystrophy type 1 heart mouse model 36 samples shares overexpression, type
- GSE293093 RNA Seq of hearts upon hepatocyte-specific overexpression of REV-ERBα in cancer cachexia 29 samples shares hepatocyte-specific, overexpression
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.