Activated-ATF6α is an ER stress-inducing oncoprotein metabolically restricting immunosurveillance [bulk RNAseq of TG-AAV-GFP/CRE/FBP1]
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 4 × AAV GFP liver, vs 4 × AAV FBP1 liver, vs 4 × AAV CRE liver, vs 4 × AAV CRE/FBP1 liver,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Activated ATF6α is a hepatic tumour driver restricting immunosurveillanceNature · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE244341_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1022436 and SRA study SRP463871. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 4 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7813950 AAV GFP liver, rep1 AAV GFP liver,
- GSM7813951 AAV GFP liver, rep2 AAV GFP liver,
- GSM7813952 AAV GFP liver, rep3 AAV GFP liver,
- GSM7813953 AAV GFP liver, rep4 AAV GFP liver,
- GSM7813954 AAV FBP1 liver, rep1 AAV FBP1 liver,
- GSM7813955 AAV FBP1 liver, rep2 AAV FBP1 liver,
- GSM7813956 AAV FBP1 liver, rep3 AAV FBP1 liver,
- GSM7813957 AAV FBP1 liver, rep4 AAV FBP1 liver,
- GSM7813958 AAV CRE liver, rep1 AAV CRE liver,
- GSM7813959 AAV CRE liver, rep2 AAV CRE liver,
- GSM7813960 AAV CRE liver, rep3 AAV CRE liver,
- GSM7813961 AAV CRE liver, rep4 AAV CRE liver,
- GSM7813962 AAV CRE/FBP1 liver, rep1 AAV CRE/FBP1 liver,
- GSM7813963 AAV CRE/FBP1 liver, rep2 AAV CRE/FBP1 liver,
- GSM7813964 AAV CRE/FBP1 liver, rep3 AAV CRE/FBP1 liver,
- GSM7813965 AAV CRE/FBP1 liver, rep4 AAV CRE/FBP1 liver,
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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.