ZFP36-family RNA-binding proteins in regulatory T cells reinforce immune homeostasis [bulk RNA-seq]
RNA-seq (gene expression) · mouse · 24 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 24 samples: 7 × nTreg FYC control vs 6 × nTreg FYC dKO vs 6 × nTreg floxed control vs 5 × eTreg floxed controlGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- ZFP36-family RNA-binding proteins in regulatory T cells reinforce immune homeostasisNature communications · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE244619_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1023903 and SRA study SRP464481. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 24 samples.
How we read this: 4 replicated groups read from 24 sample titles; they account for 24 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7822261 nTreg FYC control 1 nTreg FYC control
- GSM7822262 nTreg FYC control 2 nTreg FYC control
- GSM7822263 nTreg FYC control 3 nTreg FYC control
- GSM7822264 nTreg FYC control 4 nTreg FYC control
- GSM7822265 nTreg FYC control 5 nTreg FYC control
- GSM7822266 nTreg FYC control 6 nTreg FYC control
- GSM7822267 nTreg FYC control 7 nTreg FYC control
- GSM7822268 nTreg FYC dKO 1 nTreg FYC dKO
- GSM7822269 nTreg FYC dKO 2 nTreg FYC dKO
- GSM7822270 nTreg FYC dKO 3 nTreg FYC dKO
- GSM7822271 nTreg FYC dKO 4 nTreg FYC dKO
- GSM7822272 nTreg FYC dKO 5 nTreg FYC dKO
- GSM7822273 nTreg FYC dKO 6 nTreg FYC dKO
- GSM7822274 nTreg floxed control 1 nTreg floxed control
- GSM7822275 nTreg floxed control 2 nTreg floxed control
- GSM7822276 nTreg floxed control 3 nTreg floxed control
- GSM7822277 nTreg floxed control 4 nTreg floxed control
- GSM7822278 nTreg floxed control 5 nTreg floxed control
- GSM7822279 nTreg floxed control 6 nTreg floxed control
- GSM7822280 eTreg floxed control 1 eTreg floxed control
- GSM7822281 eTreg floxed control 2 eTreg floxed control
- GSM7822282 eTreg floxed control 3 eTreg floxed control
- GSM7822283 eTreg floxed control 4 eTreg floxed control
- GSM7822284 eTreg floxed control 5 eTreg floxed control
- GSE326641 Ubiquitin-like proteins NEDD8 and SUMO2 control epithelial homeostasis, regeneration, and inflammation [scRNA-seq] 8 samples shares homeostasis, proteins, rna-seq
- GSE217662 Decoding Trp53 regulatory program with knockout cell transcriptomic landscape analyses [scRNA-seq] 247 samples shares regulatory, rna-seq
- GSE297451 Temporal and Context-Dependent Requirements for the Transcription Factor Foxp3 in Regulatory T Cell Development and Maintenance [RNA-seq] 70 samples shares regulatory, rna-seq
- GSE268774 Lymph node macrophages drive immune tolerance and resistance to cancer therapy by expression of the immune-regulatory cytokine IL-33 [RNA-seq] 48 samples shares regulatory, rna-seq
- GSE267967 Foxp3 and BATF cooperatively direct cis-regulatory programs and gene expression for functional differentiation of Treg cells [RNA-seq] 26 samples shares regulatory, rna-seq
- GSE275780 Dual Targeting of STING and PI3Kγ Eliminates Regulatory B Cells to Overcome STING Resistance for Pancreatic Cancer Immunotherapy [RNA-seq] 17 samples shares regulatory, rna-seq
- GSE287483 Competing dynamic gene regulatory networks involved in fibroblast reprogramming to haematopoietic progenitor cells [RNA-Seq] 12 samples shares regulatory, rna-seq
- GSE238201 Loss of PPARα function promotes epigenetic dysregulation of lipid homeostasis driving ferroptosis and pyroptosis lipotoxicity in Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD) [RNA-seq] 12 samples shares homeostasis, rna-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.