Gene expression profile at single cell level of nucleus pulposus cells (NPCs) from the nucleus pulposus (NP) tissue in the mild degenerative intervertebral discs (MDD) and server degenerative intervertebral discs(SDD).
Single-cell RNA-seq · human · 13 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart.
- Organism
- Homo sapiens (human)
- Samples
- 13 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE244889_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1025305 and SRA study SRP465048. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 13 more — browse all 13 samples with per-sample file links →
- GSE230808 Shared and compartment-specific processes in nucleus pulposus and annulus fibrosus during intervertebral disc degeneration 18 samples shares intervertebral, pulposus
- GSE286069 MMP12-dependent myofibroblast formation contributes to the nucleus pulposus fibrosis and intervertebral disc degeneration 15 samples shares intervertebral, pulposus
- GSE251686 Single-cell sequencing reveals cellular heterogeneity of nucleus pulposus in intervertebral disc degeneration 6 samples shares intervertebral, pulposus
- GSE262854 Analysis of MDD and control patients by snRNA-seq 2 samples shares mdd
- GSE53987 Microarray profiling of PFC, HPC and STR from subjects with schizophrenia, bipolar, MDD or control 205 samples shares mdd
- GSE98793 Gene expression analysis in whole blood samples obtained from donors diagnosed with MDD compared to healthy controls 192 samples shares mdd
- GSE95587 Heterogeneity in neurodegenerative disease 117 samples shares degenerative
- GSE251939 Analysis of microisolated frontal cortex excitatory layer III and V pyramidal neurons reveals a neurodegenerative phenotype in individuals with Down syndrome 82 samples shares degenerative
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.