GEO series
MMP12-dependent myofibroblast formation contributes to the nucleus pulposus fibrosis and intervertebral disc degeneration
GSE286069
Homo sapiens
Expression profiling by high throughput sequencing
15 samples
2025/04/16
GPL24676
Summary
Human NP cells (NPC) are pre-conditioned in alginate for 7 days prior to monolayers expansion, and further treated by TGF-b1 for inducing fibroblastic differentiation. MMP12 is highly expressive in myofibroblastic NP cells, which depeltin by siRNA transfection results in a shift of fibroblastic/Cycling NP phenotypes towards epithelial/chondrogenic cells-like.
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Paper (PMID 40036084) ↗
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