NOTCH1 reverses immune suppression in small cell lung cancer through reactivation of STING
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 87 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Topic
- Small cell lung cancerThis series is part of our curated briefing on it.
- Samples
- 87 samples: 87 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- NOTCH1 reverses immune suppression in small cell lung cancer through reactivation of STINGThe Journal of clinical investigation · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE244947_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1026467 and SRA study SRP465376. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 87 sample titles: 87 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7832398 1_CORL88_DMSO_H3K27Ac_1
- GSM7832399 2_CORL88_DMSO_H3K27Ac_2
- GSM7832400 3_CORL88_DMSO_input
- GSM7832401 4_CORL88_TAS1440_GSI_H3K27Ac_1
- GSM7832402 5_CORL88_TAS1440_GSI_H3K27Ac_2
- GSM7832403 6_CORL88_TAS1440_GSI_input
- GSM7832404 7_CORL88_TAS1440_H3K27Ac_1
- GSM7832405 8_CORL88_TAS1440_H3K27Ac_2
- GSM7832406 9_CORL88_TAS1440_input
- GSM7832407 10_H82_NOTCH1_dox_H3K27Ac_1
- GSM7832408 11_H82_NOTCH1_dox_H3K27Ac_2
- GSM7832409 12_H82_NOTCH1_dox_input
- GSM7832410 13_H82_NOTCH1_no_dox_H3K27Ac_1
- GSM7832411 14_H82_NOTCH1_no_dox_H3K27Ac_2
- GSM7832412 15_H82_NOTCH1_no_dox_input
- GSM7832413 16_H82_parental_H3K27Ac_1
- GSM7832414 17_H82_parental_H3K27Ac_2
- GSM7832415 18_H82_parental_input
- GSM7832416 1_H82_parental
- GSM7832417 2_H82_parental
- GSM7832418 3_H82_parental
- GSM7832419 4_H82_NOTCH1_no_dox
- GSM7832420 5_H82_NOTCH1_no_dox
- GSM7832421 6_H82_NOTCH1_no_dox
- GSM7832422 7_H82_NOTCH1_dox
- GSM7832423 8_H82_NOTCH1_dox
- GSM7832424 9_H82_NOTCH1_dox
- GSM7832425 10_CORL88_DMSO
- GSM7832426 11_CORL88_DMSO
- GSM7832427 12_CORL88_DMSO
- GSM7832428 13_CORL88_TAS1440
- GSM7832429 14_CORL88_TAS1440
- GSM7832430 15_CORL88_TAS1440
- GSM7832431 16_CORL88_TAS1440_GSI
- GSM7832432 17_CORL88_TAS1440_GSI
- GSM7832433 18_CORL88_TAS1440_GSI
- GSM7832434 19_H524_parental
- GSM7832435 20_H524_parental
- GSM7832436 21_H524_parental
- GSM7832437 22_H524_NOTCH1_no_dox
+ 47 more — browse all 87 samples with per-sample file links →
- GSE318663 Vascular STING activation facilitates NK cell anti-tumor immunity in small cell lung cancer 16 samples same disease briefing · shares sting, small, lung
- GSE303043 UHRF1 drives subtype-independent aggressiveness and immune evasion in small cell lung cancer through GATA2-ST6GALNAC5 and PRC2 interactions 30 samples same disease briefing · shares small, lung
- GSE319155 Single-cell profiling of tumor lineage plasticity and the immune microenvironment in transformed small cell lung cancer 7 samples same disease briefing · shares small, lung
- GSE272512 Targeting TREX1 induces innate immune response in drug resistant Small Cell Lung Cancer 6 samples same disease briefing · shares small, lung
- GSE249362 Non-Canonical BAF and mSWI/SNF Regulates POU2F3 and are Selective Targetable Dependencies for POU2F3-Positive Small Cell Lung Cancer 125 samples same disease briefing · shares small, lung
- GSE244123 Olfactory neuroblastoma mimics molecular subtypes and lineage trajectories of small cell lung cancer 103 samples same disease briefing · shares small, lung
- GSE208446 Small cell lung cancer responds to inhibition of Jumonji enzyme in vitro and in vivo 90 samples same disease briefing · shares small, lung
- GSE255095 An in vivo screening platform using PDX models reveals KEAP1, USP22 and other drivers of chemoresistance in small cell lung cancer 67 samples same disease briefing · shares small, lung
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.