Polystyrene microplastics induce liver fibrosis and lipid deposition in mice through three hub genes revealed by the RNA-seq
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 4 × Liver_H2O vs 4 × Liver_80nm vs 4 × Liver_0.5um vs 4 × Liver_5umGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Polystyrene microplastics induce liver fibrosis and lipid deposition in mice through three hub genes revealed by the RNA-seqScientific reports · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE245069_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1026899 and SRA study SRP465694. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 4 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7835567 Liver_H2O_1 Liver_H2O
- GSM7835568 Liver_H2O_2 Liver_H2O
- GSM7835569 Liver_H2O_3 Liver_H2O
- GSM7835570 Liver_H2O_4 Liver_H2O
- GSM7835571 Liver_80nm_1 Liver_80nm
- GSM7835572 Liver_80nm_2 Liver_80nm
- GSM7835573 Liver_80nm_3 Liver_80nm
- GSM7835574 Liver_80nm_4 Liver_80nm
- GSM7835575 Liver_0.5um_1 Liver_0.5um
- GSM7835576 Liver_0.5um_2 Liver_0.5um
- GSM7835577 Liver_0.5um_3 Liver_0.5um
- GSM7835578 Liver_0.5um_4 Liver_0.5um
- GSM7835579 Liver_5um_1 Liver_5um
- GSM7835580 Liver_5um_2 Liver_5um
- GSM7835581 Liver_5um_3 Liver_5um
- GSM7835582 Liver_5um_4 Liver_5um
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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.