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Gene expression profile at single cell level of CD8+ T cells and NK cells as part of neonatal antiviral response in C57BL/6J and PrP KO mice infected with mouse cytomegalovirus (MCMV)

GSE245338 Mus musculus Expression profiling by high throughput sequencing 5 samples Submitted 2024/07/22 Platform GPL24247
Summary
Cytomegaloviral (CMV) infection poses risks to newborns, necessitating effective therapies. Given that the damage includes both viral infection of brain cells and immune system-related damage, we investigated the involvement of cellular prion protein (PrP), which plays vital roles in neuroprotection and immune regulation. We used single cell RNA sequencing (scRNA-seq) to analyze the differences in CD8+ T cell and NK cell response to congenital MCMV infection in wild type mice and strain lacking functional PrP protein (PrP KO).
Published in
Prion protein alters viral control and enhances pathology after perinatal cytomegalovirus infection
Karner D, Kvestak D, Kucan Brlic P et al. · Nature communications 2024 · PMID 39237588 · doi:10.1038/s41467-024-51931-4
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Also filed as BioProject PRJNA1027847 and SRA study SRP466287. Searching any of these in the dataset finder brings you back here.

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