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A Comparison of Hepatic Gene Expression Between Wild Type and Cgref1-depleted Mice

GSE246511 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/10/26 Platform GPL23479
Summary
Previous reports on the functions and physiological effects of secretory protein Cell Growth Regulator with EF-Hand Domain 1 (Cgref1) are limited. Primarily, our group aims to find out if Cgref1 has any major impact on different tissues. Thus, an extensive study has been carried out. Among the range of experiments and observations recorded, we compared the gene expression in the liver tissues between wild type and Cgref1-knockout mice of C57BL/6 strain using high-throughput RNA sequencing (n=3 per group). Particularly, the results revealed that Cgref1-knockout (KO) mice has significantly downregulated expression of several fatty acid biosynthesis genes – acetyl-coA carboxylases 1 (Acaca) and 2 (Acacb), and stearoyl-coA desaturase 1 (Scd1). Such finding provides supportive evidence that Cgref1 may promote de novo lipogenesis in the liver.
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Direct links to NCBI, no account and no request form: the whole study as GSE246511_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1033552 and SRA study SRP469100. Searching any of these in the dataset finder brings you back here.

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