GEO series
Neuronal TDP-43 regulates myelin formation via neurexin 1 mRNA stabilization
GSE246657
Mus musculus
Expression profiling by high throughput sequencing
10 samples
2026/02/09
GPL24247
Summary
TAR DNA-binding protein 43 (TDP-43) is a major pathological protein inextricably linked to Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Hypomyelination was detected in neuronal- specific TDP-43 knockout (TDP-43cKO) mice, and this impairment was recovered by the supplementation of cytoplasmic TDP-43 in neurons. We herein investigated the mechanisms that neuronal TDP-43 regulating neuron-oligodendrocyte interactions using the TDP-43cKO mice.
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