Mechano-oncogenic cytoskeletal remodeling drives leukemic transformation with mitochondrial vesicle-mediated STING activation
RNA-seq (gene expression) · mouse · 54 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 54 samples: 54 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Mechano-oncogenic cytoskeletal remodeling drives leukemic transformation with mitochondrial vesicle-mediated STING activationCell stem cell · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE253848_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1067558 and SRA study SRP485211. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 54 sample titles: 54 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8028677 WT, scRNAseq
- GSM8028678 CS, scRNAseq
- GSM8028679 ΔRBD-S, scRNAseq
- GSM8028680 ΔRBD-L, scRNAseq
- GSM8028681 ROCK1-KD, scRNAseq
- GSM8028682 MYLK, scRNAseq
- GSM8028683 INF2-CA, scRNAseq
- GSM8028684 MYL12B-2E, scRNAseq
- GSM8028685 MP, rep1, RNAseq
- GSM8028686 MP, rep2, RNAseq
- GSM8028687 MP, rep3, RNAseq
- GSM8028688 BM MNC, rep1, RNAseq
- GSM8028689 BM MNC, rep2, RNAseq
- GSM8028690 BM MNC, rep3, RNAseq
- GSM8028691 HSPC, rep1, RNAseq
- GSM8028692 HSPC, rep2, RNAseq
- GSM8028693 HSPC, rep3, RNAseq
- GSM8028694 CS, rep1, RNAseq
- GSM8028695 CS, rep2, RNAseq
- GSM8028696 CS, rep3, RNAseq
- GSM8028697 ΔRBD-S, rep1, RNAseq
- GSM8028698 ΔRBD-S, rep2, RNAseq
- GSM8028699 ΔRBD-S, rep3, RNAseq
- GSM8028700 ΔRBD-L, rep1, RNAseq
- GSM8028701 ΔRBD-L, rep2, RNAseq
- GSM8028702 ΔRBD-L, rep3, RNAseq
- GSM8028703 ROCK1-KD, rep1, RNAseq
- GSM8028704 ROCK1-KD, rep2, RNAseq
- GSM8028705 ROCK1-KD, rep3, RNAseq
- GSM8028706 MYLK, rep1, RNAseq
- GSM8028707 MYLK, rep2, RNAseq
- GSM8028708 MYLK, rep3, RNAseq
- GSM8028709 INF2-CA, rep1, RNAseq
- GSM8028710 INF2-CA, rep2, RNAseq
- GSM8028711 INF2-CA, rep3, RNAseq
- GSM8028712 MYL12B-2E, rep1, RNAseq
- GSM8028713 MYL12B-2E, rep2, RNAseq
- GSM8028714 MYL12B-2E, rep3, RNAseq
- GSM8028715 EV-HSPC, rep1, RNAseq
- GSM8028716 EV-HSPC, rep2, RNAseq
+ 14 more — browse all 54 samples with per-sample file links →
- GSE331176 Phagosome-mediated activation of STING by purine and pyrimidine-based bacterial cyclic dinucleotides 380 samples shares sting, activation
- GSE186649 A mitochondrial long-chain fatty acid oxidation defect in a mouse leads to dysregulation of plasma long-chain acylcarnitines, dysregulation of plasma amino acids, and an increased reliance on glucocorticoid signaling to maintain euglycemia during fasting 50 samples shares sting, mitochondrial
- GSE217803 ARID1A suppresses R-loop mediated STING-Type I Interferon pathway activation of anti-tumor immunity (RNA-Seq) 46 samples shares sting, activation
- GSE290680 Nuclear class 3 PI3K co-activates fasting-specific chromatin remodeling 36 samples shares sting, remodeling
- GSE313021 STING–IFN–CH25H lipid axis links innate immune activation to tau pathology [scRNA-seq] 16 samples shares sting, activation
- GSE320350 Nuclear class 3 PI3K co-activates fasting-specific chromatin remodeling 12 samples shares sting, remodeling
- GSE310954 Remodeling of Suppressive Melanoma Microenvironments by Particle-Mediated Modulation of the STING/IL-6/PD-L1 Axis Improves Tumor Immunity and Survival 11 samples shares sting, remodeling
- GSE217807 ARID1A suppresses R-loop mediated STING-Type I Interferon pathway activation of anti-tumor immunity 62 samples shares sting, activation
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.