GEO series
Dynamic dysregulation of the transcriptome upon deletion of Mecp2 in adult mice [CUT&RUN]
GSE246664
Mus musculus
Genome binding/occupancy profiling by high throughput sequencing
168 samples
2024/12/16
GPL24247
Summary
Loss of function mutations in methyl Cpg binding protein 2 (MECP2) cause Rett syndrome. Loss of MeCP2 causes global transcriptional dysregulation, but it was unknown whether this transcriptional dysregulation was proximal to Mecp2 function. We deleted Mecp2 from adult mice and performed a time-series CUT&RUN experiment to identify if MeCP2 binding or histone post-translational modficiations are altered immediately upon loss of MeCP2.
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Paper (PMID 39689710) ↗
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