Steroid receptor coactivation of NRF2 signaling in cardiac fibroblasts promotes resistance to oxidative stress
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 12 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Transcriptional coactivation of NRF2 signaling in cardiac fibroblasts promotes resistance to oxidative stressJournal of molecular and cellular cardiology · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE246877_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1035032 and SRA study SRP469890. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 12 sample titles: 12 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7880261 Cardiac fibroblasts, Vehicle control, 4 hours [CC1]
- GSM7880262 Cardiac fibroblasts, Vehicle control, 4 hours [CC2]
- GSM7880263 Cardiac fibroblasts, Vehicle control, 4 hours [CC3]
- GSM7880264 Cardiac fibroblasts, MCB-613-10-1, 4 hours [CD1]
- GSM7880265 Cardiac fibroblasts, MCB-613-10-1, 4 hours [CD2]
- GSM7880266 Cardiac fibroblasts, MCB-613-10-1, 4 hours [CD3]
- GSM7880267 Cardiac fibroblasts, Vehicle control, 24 hours [CC124]
- GSM7880268 Cardiac fibroblasts, Vehicle control, 24 hours [CC224]
- GSM7880269 Cardiac fibroblasts, Vehicle control, 24 hours [CC324]
- GSM7880270 Cardiac fibroblasts, MCB-613-10-1, 24 hours [CD124]
- GSM7880271 Cardiac fibroblasts, MCB-613-10-1, 24 hours [CD224]
- GSM7880272 Cardiac fibroblasts, MCB-613-10-1, 24 hours [CD324]
- GSE214188 Oxidative Stress Converts Benign Lesions to Cancer via a Self-Amplifying NRF2-EZH2 Loop [Quantseq_Nrf2Kras] 13 samples shares nrf2, oxidative
- GSE244465 The Prostacyclin Receptor is a Nrf2-regulated Immune Checkpoint in CD8+ T cells 10 samples shares nrf2, receptor
- GSE214191 Oxidative Stress Converts Benign Lesions to Cancer via a Self-Amplifying NRF2-EZH2 Loop 63 samples shares nrf2, oxidative
- GSE224756 Redox sensor KEAP1 promotes stemness and prevents reductive stress in exhausted CD8+ T cells via inhibiting NRF2 18 samples shares nrf2, promotes
- GSE218178 Adaptation to an acid microenvironment promotes pancreatic cancer organoid growth and drug resistance 183 samples shares resistance, promotes
- GSE218173 Adaptation to an acid microenvironment promotes pancreatic cancer organoid growth and drug resistance [acid] 150 samples shares resistance, promotes
- GSE328461 Osteopontin mediates acquired resistance to hypoxia-inducing antiangiogenics and promotes anti-PD-L1 refractoriness in breast cancer models 37 samples shares resistance, promotes
- GSE254704 Skeletal muscle cystathionine γ-lyase deficiency promotes obesity and insulin resistance and results in hyperglycemia and skeletal muscle injury upon HFD in mice 32 samples shares resistance, promotes
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.