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Effect of knockout ERO1α on gene expression in mTORC1 activated mouse embryonic fibroblasts

GSE246899 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/04/17 Platform GPL21273
Summary
Endoplasmic reticulum oxidoreductase 1 alpha (ERO1α) is an endoplasmic reticulum stress–related gene, which improves cell perseverance against challenges of high levels of protein misfolding during endoplasmic reticulum stress by retaining good activity of oxidative protein folding. Numerous studies have shown abnormal expression of ERo1α in various diseases, but its downstream target are not fully understood. Our work will help in the elucidation of the downstream molecular mechanism of ERO1α.
Published in
Augmented ERO1α upon mTORC1 activation induces ferroptosis resistance and tumor progression via upregulation of SLC7A11
Wang Z, Zong H, Liu W et al. · Journal of experimental & clinical cancer research : CR 2024 · PMID 38610018 · doi:10.1186/s13046-024-03039-2
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Also filed as BioProject PRJNA1035072 and SRA study SRP469906. Searching any of these in the dataset finder brings you back here.

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