Endothelial RNF20 Suppresses Endothelial-to-Mesenchymal Transition and Safeguards Physiological Angiocrine Signaling to Prevent Congenital Heart Disease
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 2 × Day10_EC_Cd31po_Rnf20_Ctr vs 2 × Day10_EC_Cd31po_Rnf20_het vs 2 × Day07_EC_Cd31po_CtrPlko vs 2 × Day07_EC_Cd31po_Rnf20_KDGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Endothelial RNF20 suppresses endothelial-to-mesenchymal transition and safeguards physiological angiocrine signaling to prevent congenital heart diseaseNature communications · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE246928_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1035110 and SRA study SRP469949. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 8 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 8 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7880588 aE10_5_heart_Isl1_Rnf20_WT
- GSM7880589 bE10_5_heart_Isl1_Rnf20_KO
- GSM7880590 01E11_5_Cdh5_Rnf20_WT_r1
- GSM7880591 02E11_5_Cdh5_Rnf20_KO_r1
- GSM7880962 Day10_EC_Cd31po_Rnf20_Ctr_r1 Day10_EC_Cd31po_Rnf20_C…
- GSM7880963 Day10_EC_Cd31po_Rnf20_Ctr_r2 Day10_EC_Cd31po_Rnf20_C…
- GSM7880964 Day10_EC_Cd31po_Rnf20_het_r1 Day10_EC_Cd31po_Rnf20_h…
- GSM7880965 Day10_EC_Cd31po_Rnf20_het_r2 Day10_EC_Cd31po_Rnf20_h…
- GSM8764272 Day07_EC_Cd31po_CtrPlko_rep1 Day07_EC_Cd31po_CtrPlko
- GSM8764273 Day07_EC_Cd31po_CtrPlko_rep2 Day07_EC_Cd31po_CtrPlko
- GSM8764274 Day07_EC_Cd31po_Rnf20_KD_rep1 Day07_EC_Cd31po_Rnf20_KD
- GSM8764275 Day07_EC_Cd31po_Rnf20_KD_rep2 Day07_EC_Cd31po_Rnf20_KD
- GSE269166 Endothelial-to-mesenchymal transition contributes to accelerated atherosclerosis in Hutchinson–Gilford progeria syndrome 14 samples shares endothelial-to-mesenchymal, endothelial, transition
- GSE274544 Single cell profiling reveals three endothelial to hematopoietic transitions with divergent isoform expression landscapes [scRNA-Seq] 1494 samples shares endothelial, transition
- GSE309071 Single cell profiling reveals three endothelial to hematopoietic transitions with divergent isoform expression landscapes [RNA-seq] 221 samples shares endothelial, transition
- GSE233056 A gene regulatory network of the endothelial-to-hematopoietic transition [RNA-seq] 28 samples shares endothelial, transition
- GSE330229 Accelerated RNA polymerase II elongation drives endothelial transition and plaque vulnerability: pharmacological targeting of the super elongation complex [RNA-seq] 24 samples shares endothelial, transition
- GSE264207 Endothelial Parkin safeguards coronary microcirculation in myocardial ischemia/reperfusion injury 16 samples shares endothelial, safeguards
- GSE261561 Contribution of VEGF-B-induced endocardial endothelial cell lineage in physiological versus pathological cardiac hypertrophy. 12 samples shares physiological, endothelial
- GSE329653 Flow induced-endothelial phenotypic transition contributes to Intracranial Aneurysm 9 samples shares endothelial, transition
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.