Endothelial Parkin safeguards coronary microcirculation in myocardial ischemia/reperfusion injury
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 4 × WT-Sham vs 4 × WT-MI/ vs 4 × KO-Sham vs 4 × KO-MI/Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE264207_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1101465 and SRA study SRP502359. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 4 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8213969 WT-Sham1 WT-Sham
- GSM8213970 WT-Sham2 WT-Sham
- GSM8213971 WT-Sham3 WT-Sham
- GSM8213972 WT-Sham4 WT-Sham
- GSM8213973 WT-MI/R1 WT-MI/
- GSM8213974 WT-MI/R2 WT-MI/
- GSM8213975 WT-MI/R3 WT-MI/
- GSM8213976 WT-MI/R4 WT-MI/
- GSM8213977 KO-Sham1 KO-Sham
- GSM8213978 KO-Sham2 KO-Sham
- GSM8213979 KO-Sham3 KO-Sham
- GSM8213980 KO-Sham4 KO-Sham
- GSM8213981 KO-MI/R1 KO-MI/
- GSM8213982 KO-MI/R2 KO-MI/
- GSM8213983 KO-MI/R3 KO-MI/
- GSM8213984 KO-MI/R4 KO-MI/
- GSE298751 Prussian blue nanoparticles targeting multiple PANoptosome-mediated PANoptosis for myocardial ischemia-reperfusion injury therapy 15 samples shares reperfusion, myocardial, ischemia
- GSE245987 Vascular endothelial S1PR2 aggravates cardiac ischemia/reperfusion injury through triggering mitochondrial dysfunctions and endothelial pyroptosis via RHO/ROCK1/DRP1/NLRP3 pathway [heart] 4 samples shares endothelial, reperfusion, ischemia
- GSE240702 Integrated Analysis of lncRNA-miRNA-mRNA Interaction Network in Myocardial Ischemia-Reperfusion Injury During Cardiopulmonary Bypass Surgery in Mouse 12 samples shares reperfusion, myocardial, ischemia
- GSE267650 Mouse kidney ischemia-reperfusion injury time course 57 samples shares reperfusion, ischemia
- GSE255933 Empagliflozin in acute myocardial infarction reduces no-reflow and preserves cardiac function by preventing endothelial damage 38 samples shares endothelial, myocardial
- GSE211951 Pulmonary gene expression after ischemia reperfusion in young and old mice 24 samples shares reperfusion, ischemia
- GSE325187 Senescent Endothelial Cells in Cerebral Microcirculation Are Key Drivers of Age-Related Blood-Brain Barrier Disruption, Microvascular Rarefaction, and Neurovascular Coupling Impairment in Mice 20 samples shares microcirculation, endothelial
- GSE254747 ZBP1-mediated apoptosis and inflammation exacerbate steatotic liver ischemia/reperfusion injury 18 samples shares reperfusion, ischemia
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.