Integrative genomic approach identifies glial transcriptomic dysregulation in the cortex of individuals with Alcohol Use Disorder
Single-cell RNA-seq · human · 73 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart. Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Homo sapiens (human)
- Samples
- 73 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Integrative Genomics Approach Identifies Glial Transcriptomic Dysregulation and Risk in the Cortex of Individuals With Alcohol Use DisorderBiological psychiatry · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE247416_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1037516 and SRA study SRP471148. Searching any of these in the dataset finder brings you back here.
The grouping that defines any comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Sample titles run Sample_35 … Sample_58 and carry no group information.
- GSM7889673 Sample_35
- GSM7889674 Sample_40
- GSM7889675 Sample_57
- GSM7889676 Sample_45
- GSM7889677 Sample_56
- GSM7889678 Sample_53
- GSM7889679 Sample_54
- GSM7889680 Sample_48
- GSM7889681 Sample_71
- GSM7889682 Sample_41
- GSM7889683 Sample_46
- GSM7889684 Sample_27
- GSM7889685 Sample_51
- GSM7889686 Sample_28
- GSM7889687 Sample_33
- GSM7889688 Sample_42
- GSM7889689 Sample_39
- GSM7889690 Sample_34
- GSM7889691 Sample_62
- GSM7889692 Sample_60
- GSM7889693 Sample_59
- GSM7889694 Sample_63
- GSM7889695 Sample_61
- GSM7889696 Sample_44
- GSM7889697 Sample_43
- GSM7889698 Sample_47
- GSM7889699 Sample_67
- GSM7889700 Sample_73
- GSM7889701 Sample_64
- GSM7889702 Sample_65
- GSM7889703 Sample_69
- GSM7889704 Sample_24
- GSM7889705 Sample_66
- GSM7889706 Sample_68
- GSM7889707 Sample_70
- GSM7889708 Sample_49
- GSM7889709 Sample_25
- GSM7889710 Sample_30
- GSM7889711 Sample_72
- GSM7889712 Sample_26
+ 33 more — browse all 73 samples with per-sample file links →
- GSE310998 Peripheral blood transcriptomics identifies cohesin–chromatin and immune dysregulation in tics and Tourette syndrome 48 samples shares dysregulation, identifies
- GSE254145 Multidimensional analysis of patient-matched primary and recurrent glioblastoma identifies microglial FCGR1A (CD64) and other FCGRs as contributors of tumor recurrence [seq] 79 samples shares identifies, glial
- GSE289574 Multi-omics Analysis of Skeletal Muscle Identifies Dysregulation of Hypoxia-Induced Genes in Peripheral Artery Disease [RNA-seq] 40 samples shares dysregulation, identifies
- GSE328351 Bulk RNA-seq of dorsolateral prefrontal cortex tissue collected during deep brain stimulation neurosurgery in obsessive-compulsive disorder and neurological controls 10 samples shares disorder, cortex
- GSE298243 Single-Cell Profiling of DNA Methylation in Autism Spectrum Disorder Prefrontal Cortex Reveals Distinct Regulatory and Aging Signatures 49 samples shares disorder, cortex
- GSE278573 A Meta-Atlas of the Developing Human Cortex Identifies Modules Driving Cell Subtype Specification [Chimeroid] 26 samples shares identifies, cortex
- GSE254707 Single-cell transcriptomic analysis identifies infiltrating plasmacytoid dendritic cells in psoriasis epidermis 4988 samples shares identifies
- GSE255685 Age-related transcriptomic differences in peripheral blood of adolescents with major depressive disorder 279 samples shares disorder
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.