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Changes in WT C2C12 Mouse Muscle Myoblast gene expression throughout differentiation.

GSE247438 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/04/03 Platform GPL21103
Summary
Genesis of skeletal muscle relies on the differentiation and fusion of mono-nucleated muscle progenitor cells into the multi-nucleated muscle fiber syncytium. The temporally-controlled cellular and morphogenetic changes underlying this process are initiated by a series of highly coordinated transcription programs. Ultimately, highly specific coordination of these transcription programs is critical for their masterfully timed transitions, which in turn facilitate the intricate generation of skeletal muscle fibers from a naïve pool of progenitor cells. This work aims to categorize changes of gene expression in vitro in C2C12 mouse muscle myoblasts while they begin to form these multinucleated myotubes.
Published in
Temporal regulation of the Mediator complex during muscle proliferation, differentiation, regeneration, aging, and disease
Kolonay DW, Sattler KM, Strawser C et al. · Frontiers in cell and developmental biology 2024 · PMID 38690566 · doi:10.3389/fcell.2024.1331563
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Direct links to NCBI, no account and no request form: the whole study as GSE247438_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1037561 and SRA study SRP471123. Searching any of these in the dataset finder brings you back here.

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