← BioTransfer GEO Dataset Finder
GEO series

Endogenous IFITM2 Involvement in Endocytosis to Regulate Neurogenesis

GSE247448 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2024/11/20 Platform GPL24247
Summary
Purpose: To gain futher insight into how IFITM2 regulates the neurogenesis ,RNA-seq was used to analyze the genome-wide changes resulting from the cerebral cortices of E13 IFITM2 conditional knock out mice and littermate wild-type. Methods: Total RNA from E13 telencephalic tissue of wild-type(WT) and Ifitm2fl/fl;Nestin-Cre mice was extracted. Specifically, Agilent 2100 Bioanalyze was used to quality controlled and quantified. then, total RNA was converted to cDNA and bound the library. RNA-sequencing analysis was used by the Illumina HiSeq 6000 platform in Annoroad Genomics Approximately one thousand transcripts showed differential expression between the wild-type(WT) and Ifitm2fl/fl;Nestin-Cre mice brain cortex, with a fold change ≥1.5 and p value <0.05. These results reflected IFITM2 plays a role in cortex development. Conclusions: RNA-seq based transcriptome characterization would provide a overall understanding how IFITM2 gene regulated the neurogenesis.
Published in
IFITM2 Modulates Endocytosis Maintaining Neural Stem Cells in Developing Neocortex
Lv Y, Zou W, Li L et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 · PMID 40052215 · doi:10.1002/advs.202501593
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE247448_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1037574 and SRA study SRP471156. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 4 more — browse all 4 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.