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Life-long persistence of nuclear RNAs in the mouse brain [Hippocampus]

GSE248100 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/04/04 Platform GPL24247
Summary
Genomic DNA residing in the nuclei of mammalian neurons can be as old as the organism itself. The life span of non-coding nuclear RNAs, which are critical for proper chromatin architecture and transcription regulation, has not been determined in adult tissues. Here, we report the identification and characterization of nuclear RNAs that do not turn over for at least two years in the adult mouse brain. These long-lived RNAs (LL-RNA) are stably retained in nuclei in a neural cell type-specific manner and are required for the maintenance of heterochromatin. Thus, the remarkable life span of neural cells may depend on both the molecular longevity of DNA for the storage of genetic information but also the extreme stability of RNA for the functional organization of chromatin.
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Also filed as BioProject PRJNA1041775 and SRA study SRP472579. Searching any of these in the dataset finder brings you back here.

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