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Maternal IgG Affects Brain Development of Mouse Pups

GSE248310 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2024/05/24 Platform GPL24247
Summary
Maternal IgG is an immunoglobulin present in breast milk and has been shown to play a role in the development of the immune system in infants. The aim of this study was to investigate the effects of maternal IgG on brain development in mouse pups. Maternal IgG immunoreactivity was observed in microglial cells of the pup brain, peaking at postnatal 8 day. In particular, strong IgG immunoreactivity was observed in the microglia in the corpus callosum and cerebellar white matter. IgG stimulation of primary cultured microglia resulted in activation of the type I interferon feedback loop by Syk. Among the IgG subclasses, IgG2a was found to have a strong influence on microglia. Analysis of FcRn KO mice that were unable to take up IgG from their mothers revealed that these mice had abnormalities in the proliferation and/or survival of microglia, oligodendrocytes, and some types of interneurons. FcRn KO mice also exhibited abnormalities in social behavior and adaptation to novel environments. This study suggests that maternal IgG affects brain development in pups.
Published in
Maternal immunoglobulin G affects brain development of mouse offspring
Sadakata M, Fujii K, Kaneko R et al. · Journal of neuroinflammation 2024 · PMID 38698428 · doi:10.1186/s12974-024-03100-z
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Also filed as BioProject PRJNA1043197 and SRA study SRP473133. Searching any of these in the dataset finder brings you back here.

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