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The catalytic domain of SETD1B regulates H3K4me3 breadth and Myc expression in MLL-r leukemia

GSE248326 Homo sapiens (human) ChIP-seq / ATAC-seq (genome binding and open chromatin) 53 samples Submitted 2025/04/28 Platform GPL24247Platform GPL24676Platform GPL18573Platform GPL19057
At a glance

ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 53 samples

What it is
ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
Organism
Homo sapiens (human)
Samples
53 samples: 38 distinct titles, 9 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Regulation of H3K4me3 breadth and MYC expression by the SETD1B catalytic domain in MLL-rearranged leukemiaLeukemia · 2025
SuperSeries — this record groups several sub-series.
Summary (written by the submitters)
This SuperSeries is composed of the SubSeries listed below.
Published in
Regulation of H3K4me3 breadth and MYC expression by the SETD1B catalytic domain in MLL-rearranged leukemia
Izumi S, Ohtani K, Matsumoto M et al. · Leukemia 2025 · PMID 40341256 · doi:10.1038/s41375-025-02638-y
This dataset
Open GSE248326 in finder → Find more RNA-seq datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE248326_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.

Also filed as BioProject PRJNA1043212 and SRA study SRP473117. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 40341256) ↗
Study design
38 distinct titles, 9 of them repeated
MA9_FLT3ITD_Setd1b_WT_NC ×3 MA9_FLT3ITD_Setd1b_dSET_NC ×3 MA9_FLT3ITD_Setd1b_dSET_IL3 ×3 MA9_FLT3ITD_Setd1b_WT_Empty ×3 MA9_FLT3ITD_Setd1b_dSET_Empty ×3 MA9_FLT3ITD_Setd1b_dSET_Myc ×3 MA9_FLT3ITD_Setd1b_dSET_Myc_H3K4me ×2 MA9_FLT3ITD_Setd1b_WT_NC_H3K4me ×2 +1 more

How we read this: Read from 53 sample titles: 38 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study

+ 13 more — browse all 53 samples with per-sample file links →

Datasets on a similar topic

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Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.