ILC2 regulate a Pi16+ fibroblast progenitor niche in the pancreas
RNA-seq (gene expression) · mouse · 32 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 32 samples: 9 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- ILC2s regulate a fibroblast progenitor niche in the pancreasScience (New York, N.Y.) · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE248387_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1043651 and SRA study SRP473286. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 2 samples read as cases, 4 as controls.
How we read this: 9 replicated groups read from 32 sample titles; they account for 29 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7912826 FB_monoculture_1 FB_monoculture
- GSM7912827 FB_monoculture_2 FB_monoculture
- GSM7912828 FB_monoculture_3 FB_monoculture
- GSM7912829 FB_monoculture_4 FB_monoculture
- GSM7912830 WT_coculture_1 WT_coculture
- GSM7912831 WT_coculture_2 WT_coculture
- GSM7912832 WT_coculture_3 WT_coculture
- GSM7912833 IL13KO_coculture_1 IL13KO_coculture
- GSM7912834 IL13KO_coculture_2 IL13KO_coculture
- GSM7912835 IL13KO_coculture_3 IL13KO_coculture
- GSM7912842 naïve_ILC2_rep1 naïve_ILC2
- GSM7912843 naïve_ILC2_rep2 naïve_ILC2
- GSM7912844 naïve_ILC2_rep3 naïve_ILC2
- GSM7912845 naïve_ILC2_rep4 naïve_ILC2
- GSM7912846 IL33_ILC2_rep1 IL33_ILC2
- GSM7912847 IL33_ILC2_rep2 IL33_ILC2
- GSM7912848 IL33_ILC2_rep3 IL33_ILC2
- GSM7912849 IL33_ILC2_rep4 IL33_ILC2
- GSM7912850 IL33_ILC2_rep5 IL33_ILC2
- GSM7912851 naive_ILC2_scRNAseq
- GSM7912852 PBS, rep 1 PBS,
- GSM7912853 PBS, rep 2 PBS,
- GSM7912854 PBS, rep 3 PBS,
- GSM7912855 AP d1, rep 1 AP d1,
- GSM7912856 AP d1, rep 2 AP d1,
- GSM7912857 AP d3, rep 1 AP d3,
- GSM7912858 AP d3, rep 2 AP d3,
- GSM7912859 AP d3, rep 3 AP d3,
- GSM7912860 AP d7, rep 1 AP d7,
- GSM7912861 AP d7, rep 2 AP d7,
- GSM9254817 Fibroblasts, RNAseq, pool1, tumours 1 and 2_3
- GSM9254818 Fibroblasts, RNAseq, pool2, tumours 4 and 5
- GSE248386 ILC2 regulate a Pi16+ fibroblast progenitor niche in the pancreas (acute pancreatitis scRNA-seq) 10 samples shares ilc2, pi16, fibroblast, progenitor, regulate, pancreas, niche
- GSE294951 GABA produced by multiple bone marrow niche cell types regulate hematopoietic stem and progenitor cells 12 samples shares progenitor, regulate, niche
- GSE261166 Transcription factor 21 regulates cardiac myofibroblast formation and fibrosis [RNA-Seq] 16 samples shares fibroblast, regulate
- GSE287483 Competing dynamic gene regulatory networks involved in fibroblast reprogramming to haematopoietic progenitor cells [RNA-Seq] 12 samples shares fibroblast, progenitor
- GSE312968 Reversible Fibroblast Trajectories Regulated by MR Underlie Diastolic Dysfunction 12 samples shares fibroblast, regulate
- GSE330351 Ferritin-mediated iron homeostasis regulates fibroblast activation and shapes post-infarction cardiac remodeling 9 samples shares fibroblast, regulate
- GSE315243 Oncogenic and tumor-suppressive forces converge on a progenitor-orchestrated niche to shape early tumorigenesis 69 samples shares progenitor, niche
- GSE230599 Cross-talk between ILC2 and Gata3high Treg locally constrains adaptive type 2 immunity 41 samples shares ilc2
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.