Nicotinamide mononucleotide promotes female germline stem cell proliferation by activating the H4K16ac-Hmgb1-Fyn-PLD signaling pathway through epigenetic remodeling
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 20 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 20 samples: 20 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Nicotinamide mononucleotide promotes female germline stem cell proliferation by activating the H4K16ac-Hmgb1-Fyn-PLD signaling pathway through epigenetic remodelingCell & bioscience · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE248653_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1045515 and SRA study SRP474350. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 20 sample titles: 20 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7918367 Control-1-Input
- GSM7918368 Control-2-Input
- GSM7918369 Control-1-ChIP
- GSM7918370 Control-2-ChIP
- GSM7918371 NMN-1-Input
- GSM7918372 NMN-2-Input
- GSM7918373 NMN-1-ChIP
- GSM7918374 NMN-2-ChIP
- GSM7918375 Control-1 [C1]
- GSM7918376 Control-2 [C2]
- GSM7918377 Control-3 [C3]
- GSM7918378 NMN-1 [T1]
- GSM7918379 NMN-2 [T2]
- GSM7918380 NMN-3 [T3]
- GSM7918381 sh-Control-1 [sh-NC1]
- GSM7918382 sh-Control-2 [sh-NC2]
- GSM7918383 sh-Control-3 [sh-NC3]
- GSM7918384 sh-Hmgb1-1 [sh-1-1]
- GSM7918385 sh-Hmgb1-2 [sh-1-2]
- GSM7918386 sh-Hmgb1-3 [sh-1-3]
- GSE300925 Lyn expression in macrophages promotes TLR activation and restricts proliferation in an isoform-independent manner 48 samples shares proliferation, promotes
- GSE85718 Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice 48 samples shares mononucleotide, nicotinamide
- GSE305975 Basal level of ATF4 promotes T cell readiness for activation-induced proliferation 29 samples shares proliferation, promotes
- GSE295816 Tissue factor pathway inhibitor promotes the migration, proliferation and colonization of MSCs by regulating CXCL12/CXCR4 signaling pathway 20 samples shares proliferation, promotes
- GSE31647 Nicotinamide mononucleotide, a key NAD+ precursor, treats the pathophysiology of diet- and age-induced diabetes 16 samples shares mononucleotide, nicotinamide
- GSE233644 Effect of nicotinamide mononucleotide on doxorubicin-induced cardiac injury in mice 16 samples shares mononucleotide, nicotinamide
- GSE288143 Basal level of ATF4 promotes T cell readiness for activation-induced proliferation [RNA-seq] 14 samples shares proliferation, promotes
- GSE262303 Nicotinamide mononucleotide mitigates neuroinflammation by enhancing GPX4-mediated ferroptosis defense in microglia 12 samples shares mononucleotide, nicotinamide
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.