The histone lysine methyltransferase MLL1 regulates the activation and functional specialization of regulatory T cells
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 12 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 6 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- The histone lysine methyltransferase MLL1 regulates the activation and functional specialization of regulatory T cellsCell reports · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE248783_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1046001 and SRA study SRP474794. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 6 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7920000 H3K4me3_YFP+_WT1 H3K4me3_YFP+_WT
- GSM7920001 H3K4me3_YFP+_KO1 H3K4me3_YFP+_KO
- GSM7920002 H3K4me3_YFP+_WT2 H3K4me3_YFP+_WT
- GSM7920003 H3K4me3_YFP+_KO2 H3K4me3_YFP+_KO
- GSM7920004 H3K4me3_RFP+YFP- Tregs_mice1 H3K4me3_RFP+YFP- Tregs_…
- GSM7920005 H3K4me3_RFP+YFP+ Tregs_mice1 H3K4me3_RFP+YFP+ Tregs_…
- GSM7920006 H3K4me3_RFP+YFP- Tregs_mice2 H3K4me3_RFP+YFP- Tregs_…
- GSM7920007 H3K4me3_RFP+YFP+ Tregs_mice2 H3K4me3_RFP+YFP+ Tregs_…
- GSM7920008 RFP+YFP-Tregs_mice1 RFP+YFP-Tregs_mice
- GSM7920009 RFP+YFP+Tregs_mice1 RFP+YFP+Tregs_mice
- GSM7920010 RFP+YFP-Tregs_mice2 RFP+YFP-Tregs_mice
- GSM7920011 RFP+YFP+Tregs_mice2 RFP+YFP+Tregs_mice
- GSE311724 Effects of loss of KAT6A on histone acetylation and methylation levels, as well as MLL1 and POLR2A occupancy 134 samples shares mll1, histone
- GSE196745 Changes in Ikaros binding and histone-modifications upon oncogenic β-catenin activation [ChIP-Seq] 30 samples shares activation, histone
- GSE303264 Functional mapping of epigenomic regulators uncovers coordinated tumor suppression by the HBO1 and MLL1 complexes [KP787] 11 samples shares mll1
- GSE282851 Functional mapping of epigenomic regulators uncovers coordinated tumor suppression by the HBO1 and MLL1 complexes [scRNA-seq] 10 samples shares mll1
- GSE296994 H3K9 di-methylation dynamics underlies mouse minor zygotic genome activation 174 samples shares activation
- GSE305975 Basal level of ATF4 promotes T cell readiness for activation-induced proliferation 29 samples shares activation
- GSE255212 Transcriptomic Signatures of WNT-Driven Pathways and Granulosa Cell-Oocyte Interaction during Primordial Follicle Activation 762 samples shares activation
- GSE331176 Phagosome-mediated activation of STING by purine and pyrimidine-based bacterial cyclic dinucleotides 380 samples shares activation
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.