AS-exos exacerbates microglial ferroptosis-driven neuroinflammation
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 4 × Sham vs 4 × MCAO vs 4 × MCAO+Ctrl-Exos vs 4 × MCAO+AS-ExosGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE248793_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1046021 and SRA study SRP474811. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 4 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7920177 Sham_1 Sham
- GSM7920178 Sham_2 Sham
- GSM7920179 Sham_3 Sham
- GSM7920180 Sham_4 Sham
- GSM7920181 MCAO_1 MCAO
- GSM7920182 MCAO_2 MCAO
- GSM7920183 MCAO_3 MCAO
- GSM7920184 MCAO_4 MCAO
- GSM7920185 MCAO+Ctrl-Exos_1 MCAO+Ctrl-Exos
- GSM7920186 MCAO+Ctrl-Exos_2 MCAO+Ctrl-Exos
- GSM7920187 MCAO+Ctrl-Exos_3 MCAO+Ctrl-Exos
- GSM7920188 MCAO+Ctrl-Exos_4 MCAO+Ctrl-Exos
- GSM7920189 MCAO+AS-Exos_1 MCAO+AS-Exos
- GSM7920190 MCAO+AS-Exos_2 MCAO+AS-Exos
- GSM7920191 MCAO+AS-Exos_3 MCAO+AS-Exos
- GSM7920192 MCAO+AS-Exos_4 MCAO+AS-Exos
- GSE310141 Microglial reactivity and neuroinflammation-driven in motivational behaviors are regulated by Orai1 channels 67 samples shares neuroinflammation, microglial
- GSE280721 Hexokinase 2 Exacerbates Mitochondrial Damage, Neuroinflammation, and Lipid accumulation by promoting ACSL4 ISGylation in Sepsis-Associated Encephalopathy 16 samples shares neuroinflammation, exacerbates
- GSE328178 Genetic suppression of myeloid receptor Clec7a attenuates microglia neuroinflammation and promotes microglial phagocytosis to delay disease progression in ALS models 14 samples shares neuroinflammation, microglial
- GSE327494 Localized PD-1 CAR T therapy reprograms neuroinflammation - mouse CAR T data. 302 samples shares neuroinflammation
- GSE254229 ALS/FTD-linked TBK1 deficiency in microglia induces an aged-like microglial signature and drives social recognition deficits in mice 141 samples shares microglial
- GSE327428 GPR34 regulation of disease-associated microglial states in mice 96 samples shares microglial
- GSE304521 SEX-DEPENDENT TYPE I INTERFERON SIGNALING EXACERBATES ALZHEIMER'S PATHOLOGY 82 samples shares exacerbates
- GSE302857 Multi-tier signaling and epigenomic reprogramming drive microglial inflammatory states and functions associated with demyelination [RNA-seq] 81 samples shares microglial
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.