GEO series
Transcriptomic and epigenomic profiling of Tet TKO neural stem cells to study NSC specification and multipotency
GSE248933
Mus musculus
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing; Other
36 samples
2024/07/23
GPL19057GPL28457GPL24247
Summary
In this study we: (1) identify genes deregulated in wildtype (WT) and Tet triple knockout (TKO) mouse embryonic stem cells (ESC) and neural stem cells (NSC). (2) Profile genome-wide changes in DNA methylation in WT and TKO ESCs and NSCs. (3) Map histone marks H3K4me1 and H3K27ac in WT and TKO ESCs and NSCs. (4) Identify promoter-interacting chromatin loops in WT and TKO NSCs.
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Paper (PMID 39196941) ↗
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